Ggcx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ggcx
gamma-glutamyl carboxylase
MGI:1927655

43 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0 involves: FVB/NJ	decreased circulating osteocalcin level	J:264734
	improved glucose tolerance	J:264734
	normal reproductive system phenotype	J:264734
	normal skeleton phenotype	J:264734
Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB/N	abnormal circulating osteocalcin level	J:264734
	decreased epididymal fat pad weight	J:264734
	decreased susceptibility to diet-induced obesity	J:264734
	hypoglycemia	J:264734
	improved glucose tolerance	J:264734
	increased carbon dioxide production	J:264734
	increased insulin sensitivity	J:264734
	increased oxygen consumption	J:264734
	normal reproductive system phenotype	J:264734
	thin body	J:264734
Ggcx^tm1Dgi/Ggcx⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	normal homeostasis/metabolism phenotype	J:120784
Ggcx^tm1Dgi/Ggcx^tm1Dgi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	internal hemorrhage	J:120784
	lethality throughout fetal growth and development, incomplete penetrance	J:120784
	neonatal lethality, complete penetrance	J:120784
	normal skeleton phenotype	J:120784
Ggcx^tm1Sinos/Ggcx⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ B6.Cg-Ggcx^tm1Sinos Speer6-ps1^{Tg(Alb-cre)21Mgn}	normal mortality/aging	J:212951
Ggcx^tm1Sinos/Ggcx^tm1Sinos Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ B6.Cg-Ggcx^tm1Sinos Speer6-ps1^{Tg(Alb-cre)21Mgn}	anemia	J:212951
	impaired blood coagulation	J:212951
	increased bleeding time	J:212951
	pregnancy-related premature death	J:212951
	premature death	J:212951
	subcutaneous hemorrhage	J:212951
	uterine hemorrhage	J:212951
	vaginal hemorrhage	J:212951
Ggcx^tm1Sinos/Ggcx^tm1Sinos Tg(AMH-cre)#Sinos/0 involves: 129S2/SvPas * C57BL/6	abnormal seminiferous tubule morphology	J:307381
	abnormal Sertoli cell morphology	J:307381
	abnormal sperm flagellum morphology	J:307381
	abnormal sperm head morphology	J:307381
	abnormal sperm midpiece morphology	J:307381
	abnormal sperm motility	J:307381
	abnormal spermatid morphology	J:307381
	abnormal testis morphology	J:307381
	coiled sperm flagellum	J:307381
	decreased hyperactivated sperm motility	J:307381
	decreased testis weight	J:307381
	increased male germ cell apoptosis	J:307381
	increased testis apoptosis	J:307381
	male infertility	J:307381
	oligozoospermia	J:307381
	normal reproductive system phenotype	J:307381
	small testis	J:307381
	teratozoospermia	J:307381
	testicular atrophy	J:307381

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23