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Ggcxtm1Sino
Targeted Allele Detail
Summary
Symbol: Ggcxtm1Sino
Name: gamma-glutamyl carboxylase; targeted mutation 1, Satoshi Inoue
MGI ID: MGI:5621178
Synonyms: Ggcxflox
Gene: Ggcx  Location: Chr6:72391291-72407695 bp, + strand  Genetic Position: Chr6, 32.27 cM, cytoband C3
Alliance: Ggcxtm1Sino page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212951
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. (J:212951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ggcx Mutation:  23 strains or lines available
References
Original:  J:212951 Azuma K, et al., Liver-specific gamma-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span. PLoS One. 2014;9(2):e88643
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory