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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
MGI:1927345
12 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Lig4tm1Pmc/\Lig4tm1Pmc
\Trp53tm1Tyj/\Trp53+
\Xrcc2tm2Pmc/\Xrcc2tm2Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		abnormal tumor morphology J:144617
increased medulloblastoma incidence J:144617
premature death J:144617
\Lig4tm1Pmc/\Lig4tm1Pmc
\Trp53tm1Tyj/\Trp53tm1Tyj
\Xrcc2tm2Pmc/\Xrcc2tm2Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
\Trp53tm1Tyj/\Trp53+
\Xrcc2tm1Pmc/\Xrcc2tm1Pmc
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		decreased body weight J:111068
increased T cell derived lymphoma incidence J:111068
\Trp53tm1Tyj/\Trp53tm1Tyj
\Xrcc2tm1Pmc/\Xrcc2tm1Pmc
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		decreased body weight J:111068
decreased neuron apoptosis J:111068
increased lymphoma incidence J:111068
increased medulloblastoma incidence J:111068
increased sarcoma incidence J:111068
increased skin tumor incidence J:111068
increased T cell derived lymphoma incidence J:111068
increased tumor incidence J:111068
perinatal lethality, incomplete penetrance J:111068
\Trp53tm1Tyj/\Trp53tm1Tyj
\Xrcc2tm2Pmc/\Xrcc2tm2Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
\Xrcc2tm1Pmc/\Xrcc2tm1Pmc
\Atmtm1Pmc/\Atmtm1Pmc
involves: 129S1/Sv 		embryonic lethality during organogenesis, complete penetrance J:111068
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory