Sorbs2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sorbs2
sorbin and SH3 domain containing 2
MGI:1924574

18 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sorbs2^{tm1.1(KOMP)Mbp}/Sorbs2^{tm1.1(KOMP)Mbp} C57BL/6N-Sorbs2^{tm1.1(KOMP)Mbp}/J	abnormal retina morphology	J:211773
	decreased circulating glucose level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating sodium level	J:211773
	increased heart rate	J:211773
	increased heart weight	J:211773
	shortened PQ interval	J:211773
	shortened PR interval	J:211773
	shortened ST segment	J:211773
Sorbs2^tm1.1Gfng/Sorbs2^tm1.1Gfng B6.129(SJL)-Sorbs2^tm1.1Gfng	no abnormal phenotype detected	J:231609
Sorbs2^tm1.2Gfng/Sorbs2^tm1.2Gfng B6.129(FVB)-Sorbs2^tm1.2Gfng	abnormal dendrite morphology	J:231609
	abnormal miniature excitatory postsynaptic currents	J:231609
	normal behavior/neurological phenotype	J:231609
	decreased prepulse inhibition	J:231609
	decreased startle reflex	J:231609
	impaired contextual conditioning behavior	J:231609
	impaired long-term object recognition memory	J:231609
	postnatal lethality, incomplete penetrance	J:231609

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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