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Sorbs2 Gene Detail
Summary
  • Symbol
    Sorbs2
  • Name
    sorbin and SH3 domain containing 2
  • Synonyms
    2010203O03Rik, 9430041O17Rik, mKIAA0777
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924574
    NCBI Gene: 234214
  • Alliance
    gene page
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45960825-46280943 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 25.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1867 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924574
 protein coding gene Chr8:45960470-46280943 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033577
 protein coding gene Chr8:44554435-44887965 (+)
A/J MGP_AJ_G0033559
 protein coding gene Chr8:42846410-43167544 (+)
AKR/J MGP_AKRJ_G0033484
 protein coding gene Chr8:44093677-44427578 (+)
BALB/cJ MGP_BALBcJ_G0033556
 protein coding gene Chr8:43013303-43335804 (+)
C3H/HeJ MGP_C3HHeJ_G0033265
 protein coding gene Chr8:44626714-44955247 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034072
 protein coding gene Chr8:46256391-46592809 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031021
 protein coding gene Chr8:39131264-39451101 (+)
CAST/EiJ MGP_CASTEiJ_G0032591
 protein coding gene Chr8:44042288-44384633 (+)
CBA/J MGP_CBAJ_G0033244
 protein coding gene Chr8:48117787-48463551 (+)
DBA/2J MGP_DBA2J_G0033397
 protein coding gene Chr8:42651938-42973471 (+)
FVB/NJ MGP_FVBNJ_G0033338
 protein coding gene Chr8:42143517-42472603 (+)
LP/J MGP_LPJ_G0033485
 protein coding gene Chr8:44572225-44911927 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033383
 protein coding gene Chr8:48207111-48555932 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034090
 protein coding gene Chr8:44258435-44592356 (+)
PWK/PhJ MGP_PWKPhJ_G0032299
 protein coding gene Chr8:42172773-42506308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032135
 protein coding gene Chr8:43403140-43745708 (+)
WSB/EiJ MGP_WSBEiJ_G0032707
 protein coding gene Chr8:44507264-44839808 (+)



Homology
more
  • Human Ortholog
    SORBS2, sorbin and SH3 domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SORBS2, sorbin and SH3 domain containing 2
  • Synonyms
    ARGBP2, PRO0618
  • Links
    NCBI Gene ID: 8470
    neXtProt AC: NX_O94875
    UniProt: O94875

  • Chr Location
    4q35.1; chr4:185585444-185956652 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, reduced dendritic complexity, decreased excitatory synaptic transmission in dentate gyrus granule cells, a reduced acoustic startle response, and impaired long-term object recognition memory and contextual fear memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    46
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031626 Ensembl Gene Model | MGI Sequence Detail 320119 C57BL/6J ±  kb
    transcript ENSMUST00000171337 Ensembl | MGI Sequence Detail 5651 Not Applicable  
    polypeptide ENSMUSP00000128000 Ensembl | MGI Sequence Detail 1214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915279
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344869 Jia Y, et al., MiR-484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2. Obesity (Silver Spring). 2023 Dec;31(12):2972-2985
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory