Cyrib Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyrib
CYFIP related Rac1 interactor B
MGI:1923520

38 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyrib^em1Erob/Cyrib^em1Erob involves: C57BL/6J	abnormal double-positive T cell morphology	J:361791
	abnormal intraepithelial T cell number	J:361791
	abnormal lymph node cell ratio	J:361791
	abnormal negative T cell selection	J:361791
	abnormal T cell clonal deletion	J:361791
	abnormal T cell differentiation	J:361791
	abnormal thymocyte activation	J:361791
	abnormal thymus cell ratio	J:361791
	decreased CD4-positive, alpha-beta T cell number	J:361791
	decreased CD8-positive, alpha-beta T cell number	J:361791
	decreased gamma-delta intraepithelial T cell number	J:361791
	decreased regulatory T cell number	J:361791
	decreased T cell number	J:361791
	decreased thymocyte number	J:361791
	increased T cell apoptosis	J:361791
	increased thymocyte apoptosis	J:361791
Cyrib^m1Dmal/Cyrib^m1Dmal involves: 129S1/Sv * 129X1/SvJ * DBA/2J	abnormal cecum morphology	J:282597
	abnormal large intestine goblet cell morphology	J:282597
	abnormal spleen morphology	J:282597
	abnormal spleen white pulp morphology	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased neutrophil cell number	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	intestinal edema	J:282597
	liver abscess	J:282597
	pulmonary parenchymal consolidation	J:282597
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib⁺ C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	decreased circulating sodium level	J:211773
	decreased exploration in new environment	J:211773
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib^{tm1b(KOMP)Wtsi} C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	edema	J:211773
	male infertility	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Cyrib^{tm1c(KOMP)Wtsi}/Cyrib^{tm1d(KOMP)Wtsi} Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * BcA17/Skmn * C57BL/6N	abnormal actin cytoskeleton morphology	J:282597
	abnormal circulating chemokine level	J:282597
	abnormal neutrophil physiology	J:282597
	increased circulating CXCL10 level	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	pulmonary parenchymal consolidation	J:282597

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24