Cyrib^em1Erob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyrib^em1Erob
• Name: CYFIP related Rac1 interactor B; endonuclease-mediated mutation 1, Ellen Robey
• MGI ID: MGI:7865346
• Synonyms: Cyrib^-, Fam49b-KO
• Gene: Cyrib Location: Chr15:63800946-63932327 bp, - strand Genetic Position: Chr15, 28.16 cM
• Alliance: Cyrib^em1Erob page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a stop codon in exon 6 of the gene. Immunoblot analysis confirmed the absence of protein expression in spleen tissues from homozygous mutant mice. (J:361791)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyrib Mutation: 88 strains or lines available

References

• Original: J:361791 Park CS, et al., Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells. Elife. 2024 Aug 19;13
• All: 1 reference(s)