Mlkl Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mlkl
mixed lineage kinase domain-like
MGI:1921818

8 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mlkl^em1Jhan/Mlkl^em1Jhan involves: C57BL/6	abnormal macrophage physiology	J:204622
	decreased sensitivity to induced cell death	J:204622
	decreased susceptibility to injury	J:204622
	normal immune system phenotype	J:204622
	normal mortality/aging	J:204622
Mlkl^m1Btlr/Mlkl⁺ C57BL/6J-Mlkl^m1Btlr	decreased cell death	J:225934
Mlkl^m1Btlr/Mlkl⁺ C57BL/6J-Mlkl^m1Btlr	decreased inflammatory response	J:225934
Mlkl^m1Btlr/Mlkl^m1Btlr C57BL/6J-Mlkl^m1Btlr	decreased cell death	J:225934
Mlkl^m1Btlr/Mlkl^m1Btlr C57BL/6J-Mlkl^m1Btlr	decreased inflammatory response	J:225934
Mlkl^m2Btlr/Mlkl⁺ C57BL/6J-Mlkl^m2Btlr	decreased cell death	J:234252
Mlkl^m2Btlr/Mlkl⁺ C57BL/6J-Mlkl^m2Btlr	decreased inflammatory response	J:234252
Mlkl^m2Btlr/Mlkl^m2Btlr C57BL/6J-Mlkl^m2Btlr	decreased cell death	J:234252
Mlkl^m2Btlr/Mlkl^m2Btlr C57BL/6J-Mlkl^m2Btlr	decreased inflammatory response	J:234252
Mlkl^m3Btlr/Mlkl⁺ C57BL/6J-Mlkl^m3Btlr	decreased cell death	J:234251
Mlkl^m3Btlr/Mlkl⁺ C57BL/6J-Mlkl^m3Btlr	decreased inflammatory response	J:234251
Mlkl^m3Btlr/Mlkl^m3Btlr C57BL/6J-Mlkl^m3Btlr	decreased cell death	J:234251
Mlkl^m3Btlr/Mlkl^m3Btlr C57BL/6J-Mlkl^m3Btlr	decreased inflammatory response	J:234251
Mlkl^M4Btlr/Mlkl^M4Btlr C57BL/6J-Mlkl^M4Btlr	decreased apoptosis	J:272831
Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa involves: BALB/cJ * C57BL/6	decreased sensitivity to induced cell death	J:204620

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23