Mlkl^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mlkl^m3Btlr
• Name: mixed lineage kinase domain-like; mutation 3, Bruce Beutler
• MGI ID: MGI:5789563
• Synonyms: mecro
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to C transversion at base pair 111,319,716 (v38) on chromosome 8, or base pair 18,741 in the GenBank genomic region NC_000074. The mutation is within the splice donor site of intron 6, one base pair away from exon 6 (out of 11 total exons). The effect of the mutation on the mRNA sequence and mutant protein expression is unknown. In the event of exon 6 skipping, the aberrant transcript would have a deletion of the 136 base pair exon 6 (corresponding to amino acids 263-308), a frame-shift, and coding of 29 aberrant amino acids followed by a premature stop codon (within exon 8) after amino acid 291. (J:234251)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

References

• Original: J:234251 Wang Y, et al., Mutagenetix entry for mecro. MGI Direct Data Submission. 2016
• All: 1 reference(s)