Mlkltm1.2Wsa
Targeted Allele Detail
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Symbol: |
Mlkltm1.2Wsa |
Name: |
mixed lineage kinase domain-like; targeted mutation 1.2, Warren S Alexander |
MGI ID: |
MGI:5614464 |
Gene: |
Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
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Alliance: |
Mlkltm1.2Wsa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:204620
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A FRT site flanked neomycin resistance cassette was inserted in intron 3 along with loxP sites upstream of exon 3 and immediately downstream of the resistance cassette. The neo cassette was removed via Flp-mediated recombination and the loxP flanked exon 3 was deleted via Cre-mediated recombination. Western blot analysis confirmed absence of protein in all tissues examined.
(J:204620)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mlkl Mutation: |
32 strains or lines available
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Original: |
J:204620 Murphy JM, et al., The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013 Sep 19;39(3):443-53 |
All: |
82 reference(s) |
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