Phenotypes associated with this allele

• Allele Symbol: Mlkl^tm1.2Wsa
• Allele Name: targeted mutation 1.2, Warren S Alexander
• Allele ID: MGI:5614464
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa	involves: BALB/cJ * C57BL/6	MGI:5614466
cx2	Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6 * C57BL/6N	MGI:5614634

Genotype
MGI:5614466

hm1

• Allelic Composition: Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:204620 )

• mouse dermal fibroblasts, mouse embryonic fibroblasts, and bone-marrow-derived macrophages are resistant to necroptosis induced by the combination of TNF, Smac-mimetic, and the caspase-inhibitor QVD-OPH compared to wild-type cells

• mice, however, appear indistinguishable from wild-type mice, no organ abnormalities are seen histologically, peripheral blood numbers are normal, and stem cells are able to compete as effectively as wild-type cells for reconstitution of the hematopoietic system of transplant recipients

Genotype
MGI:5614634

cx2

• Allelic Composition: Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa; Ripk3^tm2Vmd/Ripk3^tm2Vmd
• Genetic Background: involves: C57BL/6 * C57BL/6N

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5