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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cyld
CYLD lysine 63 deubiquitinase
MGI:1921506
61 phenotypes from 8 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cyldtm1.1Awai/Cyldtm1.1Awai
Not Specified
abnormal B cell differentiation J:126113
abnormal B cell morphology J:126113
abnormal B cell physiology J:126113
abnormal class switch recombination J:126113
abnormal humoral immune response J:126113
abnormal Peyer's patch germinal center morphology J:126113
abnormal spleen marginal zone morphology J:126113
abnormal spleen morphology J:126113
decreased B-1 B cell number J:126113
decreased IgG3 level J:126113
decreased IgM level J:126113
decreased immature B cell number J:126113
enlarged lymph nodes J:126113
enlarged Peyer's patches J:126113
enlarged spleen J:126113
increased B cell number J:126113
increased follicular B cell number J:126113
increased IgA level J:126113
increased IgG1 level J:126113
increased IgG2a level J:126113
increased IgG2b level J:126113
increased marginal zone B cell number J:126113
increased pro-B cell number J:126113
Cyldtm1.1Gmos/Cyldtm1.1Gmos
involves: BALB/cJ
abnormal lung development J:162840
abnormal lung interstitium morphology J:162840
abnormal respiratory function J:162840
atelectasis J:162840
cyanosis J:162840
decreased birth body size J:162840
impaired fibroblast cell migration J:162840
kinked tail J:162840
neonatal lethality, complete penetrance J:162840
short tail J:162840
small lung J:162840
thick lung-associated mesenchyme J:162840
Cyldtm1Awai/Cyldtm1Awai
Tg(CD19-cre/ERT2)1Cgn/?
Not Specified
abnormal mature B cell morphology J:126113
decreased B-1 B cell number J:126113
decreased immature B cell number J:126113
enlarged lymph nodes J:126113
enlarged Peyer's patches J:126113
enlarged spleen J:126113
increased B cell number J:126113
Cyldtm1Gmos/Cyldtm1Gmos
Not Specified
no abnormal phenotype detected J:162840
Cyldtm1Jdgl/Cyldtm1Jdgl
involves: 129 * C57BL/6J
decreased susceptibility to bacterial infection J:124327
decreased susceptibility to bacterial infection induced morbidity/mortality J:124327
Cyldtm1Lex/Cyldtm1Lex
involves: 129S5/SvEvBrd * C57BL/6
abnormal circulating serum albumin level J:114972
abnormal colon morphology J:114972
abnormal inflammatory response J:114972
abnormal intestinal epithelium morphology J:114972
gastric ulcer J:114972
hunched posture J:114972
normal immune system phenotype J:114972
increased incidence of tumors by chemical induction J:114972
increased susceptibility to induced colitis J:114972
premature death J:114972
thymus hyperplasia J:114972
weight loss J:114972
Cyldtm1Ref/Cyld+
B6.129-Cyldtm1Ref
increased skin papilloma incidence J:108769
Cyldtm1Ref/Cyldtm1Ref
B6.129-Cyldtm1Ref
abnormal keratinocyte proliferation J:108769
epidermal hyperplasia J:108769
increased cell proliferation J:108769
increased keratinocyte proliferation J:108769
increased skin papilloma incidence J:108769
Cyldtm1Ref/Cyldtm1Ref
Not Specified
normal immune system phenotype J:126113
Cyldtm1Scs/Cyldtm1Scs
involves: 129S1/Sv * 129X1/SvJ
abnormal B cell differentiation J:112392
abnormal enzyme/coenzyme activity J:112392
abnormal T cell number J:112392
decreased CD4-positive, alpha-beta T cell number J:112392
decreased CD8-positive, alpha-beta T cell number J:112392
increased double-positive T cell number J:112392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory