Cyld^tm1Scs
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1Scs
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Shao-Cong Sun
• MGI ID: MGI:3664438
• Synonyms: Cyld^-
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1Scs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112392
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 1. RT-PCR failed to detect transcript in mutant spleen or liver samples. Protein was absent in immunoblot analysis. (J:112392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 43 strains or lines available

References

• Original: J:112392 Reiley WW, et al., Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006 Apr;7(4):411-7
• All: 24 reference(s)