Cyld^tm1Awai
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1Awai
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Ari Waisman
• MGI ID: MGI:3761621
• Synonyms: CYLD^F
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1Awai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126113
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo was insert upstream of exoon 7 and an additional loxP site downstream of exon 7. The neo cassette was subsequently removed by cre-mediated recombination using a transient transfection of a cre-expressing plasmid. Insertion was confirmed by Southern blot. (J:126113)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 43 strains or lines available

References

• Original: J:126113 Hovelmeyer N, et al., Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med. 2007 Oct 29;204(11):2615-27
• All: 3 reference(s)