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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyldtm1Awai
targeted mutation 1, Ari Waisman
MGI:3761621
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cyldtm1Awai/Cyldtm1Awai
Tg(CD19-cre/ERT2)1Cgn/? 		Not Specified MGI:3761629


Genotype
MGI:3761629
cn1
Allelic
Composition		 Cyldtm1Awai/Cyldtm1Awai
Tg(CD19-cre/ERT2)1Cgn/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1Awai mutation (0 available); any Cyld mutation (43 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:126113 )
• 100.8+/-9.5x106 compared to 46.7+/-4.8x106 B cells in the spleen of wild mice
abnormal mature B cell morphology ( J:126113 )
• the ratio of B-1 to B-2 B cells is inverted compared to in wild-type mice in the peritoneal cavity
decreased B-1 B cell number ( J:126113 )
• the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.4+/-0.1 x106 compared to 1.4+/-0.3 x106 in wild-type mice)the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.4+/-0.1 x106 compared to 1.4+/-0.3 x106 in wild-type mice)

hematopoietic system
increased B cell number ( J:126113 )
• 100.8+/-9.5x106 compared to 46.7+/-4.8x106 B cells in the spleen of wild mice
abnormal mature B cell morphology ( J:126113 )
• the ratio of B-1 to B-2 B cells is inverted compared to in wild-type mice in the peritoneal cavity
decreased B-1 B cell number ( J:126113 )
• the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.4+/-0.1 x106 compared to 1.4+/-0.3 x106 in wild-type mice)the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.4+/-0.1 x106 compared to 1.4+/-0.3 x106 in wild-type mice)

growth/size/body
enlarged spleen ( J:126113 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory