Smg1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smg1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
MGI:1919742

43 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smg1^{Gt(AG0297)Wtsi}/Smg1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal basicranium angle	J:193626
	abnormal kidney morphology	J:193626
	abnormal tooth development	J:193626
	abnormal tooth morphology	J:193626
	normal cellular phenotype	J:193626
	chronic inflammation	J:193626
	decreased circulating interleukin-1 beta level	J:193626
	decreased tumor-free survival time	J:193626
	enlarged liver	J:193626
	enlarged spleen	J:193626
	normal hematopoietic system phenotype	J:193626
	hepatic steatosis	J:193626
	normal homeostasis/metabolism phenotype	J:193626
	increased B cell derived lymphoma incidence	J:193626
	increased body length	J:193626
	increased body size	J:193626
	increased body weight	J:193626
	increased circulating interleukin-6 level	J:193626
	increased lung adenocarcinoma incidence	J:193626
	increased lymphoma incidence	J:193626
	increased tumor incidence	J:193626
	prognathia	J:193626
	normal skeleton phenotype	J:193626
Smg1^{Gt(AG0297)Wtsi}/Smg1^{Gt(AG0297)Wtsi} involves: 129P2/OlaHsd * C57BL/6	embryonic lethality between implantation and placentation, complete penetrance	J:193626
Smg1^{Gt(RRT449)Byg}/Smg1^{Gt(RRT449)Byg} B6.129P2-Smg1^{Gt(RRT449)Byg}	abnormal cardiovascular development	J:196053
	abnormal cell physiology	J:196053
	abnormal eye development	J:196053
	abnormal heart development	J:196053
	absent optic pit	J:196053
	decreased cell proliferation	J:196053
	decreased embryo size	J:196053
	delayed brain development	J:196053
	delayed embryo turning	J:196053
	embryonic growth arrest	J:196053
	embryonic lethality during organogenesis, complete penetrance	J:196053
	failure of heart looping	J:196053
	increased embryonic tissue cell apoptosis	J:196053
	internal hemorrhage	J:196053
Smg1^{tm1b(EUCOMM)Hmgu}/Smg1⁺ C57BL/6N-Smg1^{tm1b(EUCOMM)Hmgu}/Wtsi	increased circulating bilirubin level	J:211773
Smg1^{tm1b(EUCOMM)Hmgu}/Smg1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Smg1^{tm1b(EUCOMM)Hmgu}/Wtsi	abnormal trophoblast layer morphology	J:261316
	embryonic lethality during organogenesis, incomplete penetrance	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773

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