Smg1^{Gt(RRT449)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Smg1^{Gt(RRT449)Byg}
• Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase; gene trap RRT449, BayGenomics
• MGI ID: MGI:4338581
• Synonyms: Smg1^gt
• Gene: Smg1 Location: Chr7:117730531-117842893 bp, - strand Genetic Position: Chr7, 63.44 cM
• Alliance: Smg1^{Gt(RRT449)Byg} page

Developmental defects in Smg1^{Gt(RRT449)Byg}/Smg1^{Gt(RRT449)Byg} embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RRT449
• Germline Transmission: Earliest citation of germline transmission: J:196053
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• The gene trap inserted into intron 12. RT-PCR confirmed the absence of transcript expression. (J:196053)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRT449	CL265495 ; (MGI Seq Detail)	5' RACE	Chr7:117794291-117795203 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  48 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Smg1^{Gt(RRT449)Byg} allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smg1 Mutation: 222 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)