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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmprss6
transmembrane serine protease 6
MGI:1919003
58 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tmprss6hem8/Tmprss6hem8
C57BL/6J-Tmprss6hem8 		abnormal iron homeostasis J:237155
alopecia J:237155
decreased circulating iron level J:237155
decreased liver iron level J:237155
decreased mean corpuscular hemoglobin J:237155
decreased mean corpuscular volume J:237155
normal hematopoietic system phenotype J:237155
increased circulating unsaturated transferrin level J:237155
Tmprss6hem8/Tmprss6tm1Dgen
involves: C57BL/6 * C57BL/6J 		abnormal iron homeostasis J:237155
decreased circulating iron level J:237155
decreased liver iron level J:237155
decreased mean corpuscular hemoglobin J:237155
decreased mean corpuscular volume J:237155
increased circulating unsaturated transferrin level J:237155
reticulocytosis J:237155
Tmprss6m2Btlr/Tmprss6m2Btlr
C57BL/6J-Tmprss6m2Btlr 		alopecia J:140084
decreased circulating iron level J:140084
progressive hair loss J:140084
Tmprss6m3Btlr/Tmprss6m3Btlr
C57BL/6J-Tmprss6m3Btlr 		alopecia J:143779
decreased circulating iron level J:143779
reduced female fertility J:143779
sparse hair J:143779
Tmprss6m5Btlr/Tmprss6m5Btlr
C57BL/6J-Tmprss6m5Btlr 		focal hair loss J:236692
Tmprss6msk/Tmprss6msk
C57BL/6J-Tmprss6msk 		abnormal intestinal mineral absorption J:134446
abnormal iron homeostasis J:134446
alopecia J:134446
decreased body size J:134446
decreased circulating iron level J:134446
decreased hemoglobin content J:134446
decreased mean corpuscular volume J:134446
decreased spleen iron level J:134446
female infertility J:134446
microcytic anemia J:134446
progressive hair loss J:134446
Tmprss6tm1b(EUCOMM)Wtsi/Tmprss6tm1b(EUCOMM)Wtsi
C57BL/6N-Tmprss6tm1b(EUCOMM)Wtsi/Ics 		abnormal coat appearance J:211773
abnormal coat/ hair morphology J:211773
abnormal coat/hair pigmentation J:211773
abnormal skin morphology J:211773
decreased CD8-positive, alpha-beta T cell number J:211773
decreased exploration in new environment J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased locomotor activity J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
decreased NK cell number J:211773
decreased prepulse inhibition J:211773
immune system phenotype J:211773
increased CD11b-high dendritic cell number J:211773
increased circulating calcium level J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased fasting circulating glucose level J:211773
increased heart weight J:211773
increased Ly6C-positive mature NK cell number J:211773
short tibia J:211773
Tmprss6tm1Dgen/Tmprss6+
B6.129P2-Tmprss6tm1Dgen/Crl 		decreased circulating iron level J:160248
decreased liver iron level J:160248
decreased mean corpuscular hemoglobin concentration J:160248
decreased mean corpuscular volume J:160248
decreased spleen iron level J:160248
maternal effect J:160248
Tmprss6tm1Dgen/Tmprss6+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased mean corpuscular hemoglobin concentration J:160248
decreased mean corpuscular volume J:160248
Tmprss6tm1Dgen/Tmprss6tm1Dgen
B6.129P2-Tmprss6tm1Dgen/Crl 		abnormal erythrocyte morphology J:160248
abnormal iron homeostasis J:237155
alopecia J:160248, J:237155
decreased body size J:160248
decreased circulating iron level J:160248, J:237155
decreased erythrocyte cell number J:160248
decreased hematocrit J:160248
decreased hemoglobin content J:160248
decreased liver iron level J:160248, J:237155
decreased mean corpuscular hemoglobin J:237155
decreased mean corpuscular hemoglobin concentration J:160248
decreased mean corpuscular volume J:160248, J:237155
decreased spleen iron level J:160248
extramedullary hematopoiesis J:160248
increased circulating unsaturated transferrin level J:237155
increased red blood cell distribution width J:160248
increased spleen weight J:160248
microcytic anemia J:160248
postnatal lethality, incomplete penetrance J:160248
reticulocytosis J:237155
Tmprss6tm1Dgen/Tmprss6tm1Dgen
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal iron level J:160248
alopecia J:160248
decreased erythrocyte cell number J:160248
decreased heart iron level J:160248
decreased hematocrit J:160248
decreased hemoglobin content J:160248
decreased liver iron level J:160248
decreased mean corpuscular hemoglobin concentration J:160248
decreased mean corpuscular volume J:160248
decreased pancreas iron level J:160248
increased red blood cell distribution width J:160248
microcytic anemia J:160248
normal mortality/aging J:160248
Tmprss6tm1Otin/Tmprss6tm1Otin
involves: 129P2/OlaHsd * C57BL/6 		decreased hemoglobin content J:185154
microcytosis J:185154
Tmprss6tm1Otin/Tmprss6tm1Otin
involves: 129P2/OlaHsd * C57BL/6J 		abnormal erythrocyte morphology J:138734
abnormal hair follicle infundibulum morphology J:138734
abnormal hair follicle morphology J:138734
abnormal iron level J:138734
abnormal ovary development J:138734
alopecia J:138734
anemia J:138734
anisopoikilocytosis J:138734
decreased circulating iron level J:138734
female infertility J:138734
pallor J:138734
postnatal growth retardation J:138734
thin hair follicle outer root sheath J:138734
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory