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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wwtr1
WW domain containing transcription regulator 1
MGI:1917649
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Lats1tm1Noj/\Lats1tm1Noj
\Lats2tm1.1Dupa/\Lats2tm1.1Dupa
\Wwtr1tm1.2Eno/\Wwtr1tm1.2Eno
\Yap1tm1.1Dupa/\Yap1tm1.1Dupa
involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas 		abnormal bile duct epithelium morphology J:223215
enlarged liver J:223215
\Mob1atm1.1Asuz/\Mob1atm1.1Asuz
\Mob1bGt(CC0690)Wtsi/\Mob1bGt(CC0690)Wtsi
\Wwtr1tm1Hku/\Wwtr1tm1Hku
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
\Wwtr1tm1.1Eno/\Wwtr1+
\Yap1tm1.1Eno/\Yap1tm1.1Eno
\Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N 		increased cardiomyocyte apoptosis J:200670
myocardium hypoplasia J:200670
postnatal lethality, complete penetrance J:200670
thin myocardium J:200670
\Wwtr1tm1.1Eno/\Wwtr1tm1.1Eno
\Yap1tm1.1Eno/\Yap1+
\Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N 		abnormal atrial thrombosis J:200670
dilated cardiomyopathy J:200670
premature death J:200670
\Wwtr1tm1.1Eno/\Wwtr1tm1.1Eno
\Yap1tm1.1Eno/\Yap1tm1.1Eno
\Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N 		abnormal heart morphology J:200670
neonatal lethality, complete penetrance J:200670
\Wwtr1tm1.2Hmc/\Wwtr1tm1.2Hmc
\Yap1tm1.2Hmc/\Yap1+
\Tg(Myh11-cre,-EGFP)2Mik/0
involves: 129 * C57BL/6 * DBA/2 		abnormal mitochondrial physiology J:344215
\Wwtr1tm1Hku/\Wwtr1tm1Hku
\Yap1tm1Smil/\Yap1tm1Smil
involves: 129S/SvEv 		embryonic lethality before implantation, complete penetrance J:147050
\Wwtr1tm1Hmc/\Wwtr1tm1Hmc
\Yap1tm1Hmc/\Yap1tm1Hmc
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl 		abnormal kidney development J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
kidney cyst J:195266
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory