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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pggt1b
protein geranylgeranyltransferase type I, beta subunit
MGI:1917514
23 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Fntbtm1.1Mbrg/\Fntbtm1.1Mbrg
\Pggt1btm1Mbrg/\Pggt1btm1Mbrg
involves: 129P2/OlaHsd * C57BL/6 		increased fibroblast apoptosis J:158937
\Fntbtm1.1Mbrg/\Fntbtm1.1Mbrg
\Pggt1btm1Mbrg/\Pggt1btm1Mbrg
\Tg(KRT14-cre)1Amc/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal skin physiology J:158528
decreased hair follicle number J:158528
thin epidermis J:158528
\Fntbtm1.1Mbrg/\Fntbtm1.2Mbrg
\Krastm4Tyj/\Kras+
\Pggt1btm1Mbrg/\Pggt1btm1.1Mbrg
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N 		abnormal lung epithelium morphology J:158937
decreased tumor growth/size J:158937
increased lung adenoma incidence J:158937
increased lung carcinoma incidence J:158937
increased lung tumor incidence J:158937
\Fntbtm1.1Mbrg/\Fntbtm1.2Mbrg
\Krastm4Tyj/\Kras+
\Pggt1btm1Mbrg/\Pggt1btm1.1Mbrg
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N 		decreased tumor growth/size J:158937
increased lung tumor incidence J:158937
premature death J:158937
\Krastm4Tyj/\Kras+
\Pggt1btm1Mbrg/\Pggt1b+
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal definitive hematopoiesis J:122107
abnormal liver morphology J:122107
abnormal spleen morphology J:122107
decreased lymphocyte cell number J:122107
increased lung adenocarcinoma incidence J:122107
increased lung adenoma incidence J:122107
increased lung tumor incidence J:122107
increased lung weight J:122107
increased neutrophil cell number J:122107
postnatal lethality, incomplete penetrance J:122107
respiratory distress J:122107
weight loss J:122107
\Krastm4Tyj/\Kras+
\Pggt1btm1Mbrg/\Pggt1btm1Mbrg
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		increased lung adenoma incidence J:122107
increased lung tumor incidence J:122107
increased lung weight J:122107
postnatal growth retardation J:122107
postnatal lethality, incomplete penetrance J:122107
\Pggt1btm1Mbrg/\Pggt1btm1Mbrg
\Krastm4Tyj/\Kras+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal cell morphology J:122107
decreased cell proliferation J:122107
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory