Fntb^tm1.2Mbrg
Targeted Allele Detail

Summary

• Symbol: Fntb^tm1.2Mbrg
• Name: farnesyltransferase, CAAX box, beta; targeted mutation 1.2, Martin O Bergo
• MGI ID: MGI:4441483
• Synonyms: Fntb^delta
• Gene: Fntb Location: Chr12:76884014-76968188 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Fntb^tm1.2Mbrg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158937
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two loxP sites were inserted 1kb upstream and 1kb downstream of exon 1, followed by a floxed neo cassette. Neo cassette and exon1 with the promoter sequence were deleted by sequential Cre-mediated recombination. (J:158937)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fntb Mutation: 207 strains or lines available

References

• Original: J:158937 Liu M, et al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6471-6
• All: 2 reference(s)