Cap2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cap2
cyclase associated actin cytoskeleton regulatory protein 2
MGI:1914502

49 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cap2^{tm1a(EUCOMM)Wtsi}/Cap2⁺ C57BL/6N-Cap2^{tm1a(EUCOMM)Wtsi}/Ieg	abnormal locomotor activation	J:165965
	cataract	J:165965
	decreased body weight	J:165965
Cap2^{tm1a(EUCOMM)Wtsi}/Cap2⁺ involves: C57BL/6J * C57BL/6N	decreased survivor rate	J:234044
Cap2^{tm1a(EUCOMM)Wtsi}/Cap2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cap2^{tm1a(EUCOMM)Wtsi}/Ieg	decreased body weight	J:165965
	decreased circulating triglyceride level	J:165965
Cap2^{tm1a(EUCOMM)Wtsi}/Cap2^{tm1a(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	abnormal impulse conducting system conduction	J:234044
	cardiac interstitial fibrosis	J:234044
	congestive heart failure	J:234044
	decreased aerobic running capacity	J:234044
	decreased body weight	J:234044
	decreased grip strength	J:234044
	decreased survivor rate	J:234044
	decreased ventricle muscle contractility	J:234044
	dilated cardiomyopathy	J:234044
	dilated heart left ventricle	J:234044
	eye inflammation	J:234044
	normal homeostasis/metabolism phenotype	J:234044
	increased susceptibility to infection	J:234044
	microphthalmia	J:234044
	postnatal growth retardation	J:234044
	postnatal lethality, incomplete penetrance	J:234044
	premature death	J:234044
	prolonged HV interval	J:234044
	prolonged QRS complex duration	J:234044
	prolonged QT interval	J:234044
	small pupil	J:234044
Cap2^{tm1b(EUCOMM)Wtsi}/Cap2⁺ C57BL/6N-Cap2^{tm1b(EUCOMM)Wtsi}/Ieg	decreased mean corpuscular hemoglobin	J:211773
	increased red blood cell distribution width	J:211773
	prolonged QT interval	J:211773
	prolonged RR interval	J:211773
	prolonged ST segment	J:211773
Cap2^{tm1b(EUCOMM)Wtsi}/Cap2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cap2^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, incomplete penetrance	J:211773
Cap2^{tm1c(EUCOMM)Wtsi}/Cap2^{tm1c(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	no abnormal phenotype detected	J:234044
Cap2^{tm1c(EUCOMM)Wtsi}/Cap2^{tm1c(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds/0 involves: C57BL/6J * C57BL/6N	abnormal impulse conducting system conduction	J:234044
	atrioventricular block	J:234044
	normal cardiovascular system phenotype	J:234044
	decreased heart rate	J:234044
	premature death	J:234044
	prolonged HV interval	J:234044
	prolonged QRS complex duration	J:234044
	prolonged RR interval	J:234044
	sinus bradycardia	J:234044
Cap2^{tm1e(EUCOMM)Wtsi}/Cap2^{tm1e(EUCOMM)Wtsi} C57BL/6N-Cap2^{tm1e(EUCOMM)Wtsi}	abnormal heart morphology	J:226742
	abnormal I band morphology	J:226742
	abnormal M line morphology	J:226742
	abnormal myocardial fiber morphology	J:226742
	abnormal myocardial fiber physiology	J:226742
	abnormal myocardium layer morphology	J:226742
	abnormal sarcomere morphology	J:226742
	abnormal ventricle myocardium morphology	J:226742
	cardiac fibrosis	J:226742
	decreased body weight	J:226742
	decreased heart rate	J:226742
	decreased myocardial fiber number	J:226742
	dilated cardiomyopathy	J:226742
	dilated heart atrium	J:226742
	dilated heart right atrium	J:226742
	dilated heart ventricle	J:226742
	enlarged heart	J:226742
	postnatal lethality, incomplete penetrance	J:226742
	premature death	J:226742
	prolonged PQ interval	J:226742
	prolonged QRS complex duration	J:226742
	prolonged QT interval	J:226742

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