Cap2^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cap2^{tm1e(EUCOMM)Wtsi}
• Name: cyclase associated actin cytoskeleton regulatory protein 2; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:5776537
• Synonyms: Cap2^gt
• Gene: Cap2 Location: Chr13:46655379-46803757 bp, + strand Genetic Position: Chr13, 23.83 cM
• Alliance: Cap2^{tm1e(EUCOMM)Wtsi} page
• IMPC: Cap2 gene page

Mutation origin

• Mutant Cell Lines: EPD0155_4_B07, EPD0155_4_D07
• Germline Transmission: Earliest citation of germline transmission: J:226742
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 46684001 of Chromosome 13 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. This targeted allele has lost the 3' loxP site present in the tm1a allele. This mutation cannot be converted into a conditional allele. (J:155845)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cap2 Mutation: 51 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 8 reference(s)