Bccip Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bccip
BRCA2 and CDKN1A interacting protein
MGI:1913415

34 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bccip^{tm1b(EUCOMM)Hmgu}/Bccip⁺ C57BL/6N-Bccip^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	decreased exploration in new environment	J:211773
Bccip^{tm1b(EUCOMM)Hmgu}/Bccip^{tm1b(EUCOMM)Hmgu} C57BL/6N-Bccip^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Bccip^{tm1d(EUCOMM)Hmgu}/Bccip⁺ involves: C57BL/6N	abnormal hepatocyte morphology	J:297226
	abnormal liver morphology	J:297226
	normal behavior/neurological phenotype	J:297226
	chronic inflammation	J:297226
	chronic liver inflammation	J:297226
	decreased spleen red pulp amount	J:297226
	enlarged spleen	J:297226
	hepatic necrosis	J:297226
	increased B cell derived lymphoma incidence	J:297226
	increased hepatocellular carcinoma incidence	J:297226
	increased tumor cell proliferation	J:297226
	Mallory bodies	J:297226
	normal mortality/aging	J:297226
Bccip^{tm1d(EUCOMM)Hmgu}/Bccip^{tm1d(EUCOMM)Hmgu} involves: C57BL/6N	embryonic lethality, complete penetrance	J:297226
Tg(EIIa-cre)C5379Lmgd/0 Tg(Rnu6-RNAi:Bccip)4Zshn/0 involves: C57BL/6 * FVB/N	abnormal embryo development	J:176115
	abnormal mesoderm development	J:176115
	absent amniotic cavity	J:176115
	absent neural plate	J:176115
	absent notochord	J:176115
	decreased cell proliferation	J:176115
	decreased inner cell mass proliferation	J:176115
	decreased litter size	J:176115
	embryonic growth arrest	J:176115
	embryonic growth retardation	J:176115
	embryonic lethality during organogenesis	J:176115
	increased embryonic tissue cell apoptosis	J:176115
Tg(Rnu6-RNAi:Bccip)4Zshn/0 FVB/N-Tg(Rnu6-RNAi:Bccip)4Zshn	chromosomal instability	J:176115
	decreased cell proliferation	J:176115
	impaired double-strand DNA break repair	J:176115
	increased cellular sensitivity to gamma-irradiation induced cell death	J:176115
Tg(Rnu6-RNAi:Bccip)4Zshn/Tg(Rnu6-RNAi:Bccip)4Zshn FVB/N-Tg(Rnu6-RNAi:Bccip)4Zshn	no abnormal phenotype detected	J:176115

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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