Actl6a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Actl6a
actin-like 6A
MGI:1861453

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Actl6a^em1(IMPC)J/Actl6a⁺ C57BL/6NJ-Actl6a^em1(IMPC)J/Mmjax	decreased circulating bilirubin level	J:211773
	decreased circulating phosphate level	J:211773
	decreased exploration in new environment	J:211773
Actl6a^em1(IMPC)J/Actl6a^em1(IMPC)J C57BL/6NJ-Actl6a^em1(IMPC)J/Mmjax	preweaning lethality, complete penetrance	J:211773
Actl6a^tm1.1Grc/Actl6a⁺ Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6J * CBA	decreased common myeloid progenitor cell number	J:192124
	decreased granulocyte number	J:192124
	decreased macrophage cell number	J:192124
Actl6a^tm1.1Grc/Actl6a^tm1.1Grc Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6J * CBA	abnormal bone marrow cell physiology	J:192124
	abnormal definitive hematopoiesis	J:192124
	abnormal hematopoietic stem cell physiology	J:192124
	anemia	J:192124
	decreased B cell number	J:192124
	decreased bone marrow cell number	J:192124
	decreased common myeloid progenitor cell number	J:192124
	decreased erythrocyte cell number	J:192124
	decreased erythroid progenitor cell number	J:192124
	decreased granulocyte number	J:192124
	decreased hematopoietic stem cell number	J:192124
	decreased hematopoietic stem cell proliferation	J:192124
	decreased hemoglobin content	J:192124
	decreased leukocyte cell number	J:192124
	decreased lymphocyte cell number	J:192124
	decreased macrophage cell number	J:192124
	decreased megakaryocyte cell number	J:192124
	decreased monocyte cell number	J:192124
	increased erythroblast number	J:192124
	polycythemia	J:192124
	premature death	J:192124
	thrombocytopenia	J:192124
Actl6a^tm1.2Grc/Actl6a^tm1.2Grc involves: 129S6/SvEvTac	embryonic lethality, complete penetrance	J:192124

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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