About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr2c2
nuclear receptor subfamily 2, group C, member 2
MGI:1352466
77 phenotypes from 4 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Nr2c2tm1Amj/Nr2c2tm1Amj
B6.129-Nr2c2tm1Amj 		abnormal blood homeostasis J:169333
abnormal eating behavior J:169333
abnormal energy homeostasis J:169333
abnormal gas homeostasis J:169333
abnormal glucose homeostasis J:169333
abnormal lipid homeostasis J:169333
abnormal white adipose tissue physiology J:169333
decreased abdominal fat pad weight J:169333
decreased body fat mass J:169333
decreased body weight J:169333
decreased brown adipose tissue mass J:169333
decreased circulating alanine transaminase level J:169333
decreased circulating aspartate transaminase level J:169333
decreased circulating cholesterol level J:169333
decreased circulating glucose level J:169333
decreased circulating insulin level J:169333
decreased circulating LDL cholesterol level J:169333
decreased circulating triglyceride level J:169333
decreased epididymal fat pad weight J:169333
decreased inflammatory response J:169333
decreased liver triglyceride level J:169333
decreased susceptibility to age-related hepatic steatosis J:169333
decreased susceptibility to diet-induced hepatic steatosis J:169333
decreased susceptibility to diet-induced obesity J:169333
decreased white fat cell size J:169333
embryonic lethality during organogenesis, incomplete penetrance J:169333
increased carbon dioxide production J:169333
increased energy expenditure J:169333
increased oxygen consumption J:169333
increased respiratory quotient J:169333
Nr2c2tm1b(EUCOMM)Wtsi/Nr2c2+
C57BL/6N-Nr2c2tm1b(EUCOMM)Wtsi/Bay 		impaired glucose tolerance J:211773
Nr2c2tm1b(EUCOMM)Wtsi/Nr2c2tm1b(EUCOMM)Wtsi
C57BL/6N-Nr2c2tm1b(EUCOMM)Wtsi/Bay 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, incomplete penetrance J:211773
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal mechanical nociception J:197895
decreased neuron number J:197895
decreased pruritus J:197895
increased chemical nociceptive threshold J:197895
increased thermal nociceptive threshold J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Camk2a-cre)#Stl/0
involves: BALB/c * C57BL 		normal integument phenotype J:197895
normal nervous system phenotype J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal mechanical nociception J:197895
abnormal neuron physiology J:197895
abnormal sympathetic afferent fiber morphology J:197895
abnormal touch/ nociception J:197895
normal behavior/neurological phenotype J:197895
decreased anxiety-related response J:197895
decreased body size J:197895
decreased neuron number J:197895
decreased pruritus J:197895
impaired coordination J:197895
increased chemical nociceptive threshold J:197895
increased thermal nociceptive threshold J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Nr5a1-cre)#Lowl/0
involves: FVB 		normal integument phenotype J:197895
normal nervous system phenotype J:197895
Nr2c2tm1Chc/Nr2c2tm1Chc
Not Specified 		abnormal corpus luteum morphology J:133000
abnormal estrous cycle J:133000
abnormal hemoglobin J:121628
abnormal internal female genitalia morphology J:133000
abnormal ovary physiology J:133000
abnormal ovulation J:133000
arrest of male meiosis J:91602
decreased body size J:91602
decreased circulating estradiol level J:133000
decreased circulating progesterone level J:133000
decreased corpora lutea number J:133000
decreased litter size J:133000
decreased mature ovarian follicle number J:133000
decreased superovulation rate J:133000
decreased testis weight J:91602
delayed vaginal opening J:133000
impaired ovarian folliculogenesis J:133000
increased atretic ovarian follicle number J:133000
increased granulosa cell apoptosis J:133000
multinucleated giant male germ cells J:121628
oligozoospermia J:91602
prolonged diestrus J:133000
prolonged estrous cycle J:133000
reduced female fertility J:133000
reduced male fertility J:91602
seminiferous tubule degeneration J:91602
short estrus J:133000
short proestrus J:133000
small ovary J:133000
small uterus J:133000
small vagina J:133000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory