Nr2c2^tm1Chc
Targeted Allele Detail

Summary

• Symbol: Nr2c2^tm1Chc
• Name: nuclear receptor subfamily 2, group C, member 2; targeted mutation 1, Chawnshang Chang
• MGI ID: MGI:3050563
• Synonyms: Tr4^-, TR4^-
• Gene: Nr2c2 Location: Chr6:92068426-92150039 bp, + strand Genetic Position: Chr6, 41.03 cM
• Alliance: Nr2c2^tm1Chc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91602
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ/MCI-neo cassette replaced most of exon 4 and all of exon 5. PCR, RT-PCR and Southern blot confirmed recombination and expression in homozygous mutants and decreased expression in heterozygotes. (J:91602)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2c2 Mutation: 67 strains or lines available

References

• Original: J:91602 Mu X, et al., Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol Cell Biol. 2004 Jul;24(13):5887-99
• All: 19 reference(s)