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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wdr1
WD repeat domain 1
MGI:1337100
44 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Wdr1Gt(XN462)Byg/Wdr1Gt(XN462)Byg
involves: 129P2/OlaHsd 		embryonic lethality between implantation and somite formation, incomplete penetrance J:134092
embryonic lethality during organogenesis, complete penetrance J:134092
Wdr1Gt(XN462)Byg/Wdr1rede
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:134092
ear inflammation J:134092
postnatal lethality, incomplete penetrance J:134092
skin inflammation J:134092
thrombocytopenia J:134092
Wdr1rede/Wdr1rede
C57BL/6-Wdr1rede 		abnormal erythropoiesis J:134092
abnormal megakaryocyte morphology J:134092
abnormal myelopoiesis J:134092
abnormal osteoclast physiology J:134092
abnormal platelet alpha-granule morphology J:134092
abnormal platelet dense granule morphology J:134092
abnormal platelet morphology J:134092
abnormal platelet shape J:134092
abnormal thrombopoiesis J:134092
anemia J:134092
ear inflammation J:134092
epidermal hyperplasia J:134092
impaired neutrophil chemotaxis J:134092
increased bleeding time J:134092
increased mean platelet volume J:134092
increased megakaryocyte cell number J:134092
increased neutrophil cell number J:134092
increased osteoclast cell number J:134092
skin inflammation J:134092
thrombocytopenia J:134092
Wdr1rede/Wdr1rede
Not Specified 		increased inflammatory response J:85113
Wdr1tm1.1Zzy/Wdr1+
Tg(Myh6-cre)1Xya/0
involves: 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:211364
Wdr1tm1.1Zzy/Wdr1tm1.1Zzy
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal myocardial fiber morphology J:211364
cardiac hypertrophy J:211364
increased heart weight J:211364
increased myocardial fiber size J:211364
premature death J:211364
Wdr1tm1.1Zzy/Wdr1tm1.1Zzy
Tg(Myh6-cre)1Xya/0
involves: 129S6/SvEvTac * C57BL/6J 		abnormal heart electrocardiography waveform feature J:211364
abnormal heart left ventricle morphology J:211364
abnormal interventricular septum morphology J:211364
abnormal myocardial fiber morphology J:211364
abnormal myocardium layer morphology J:211364
abnormal T wave J:211364
cardiac hypertrophy J:211364
decreased heart rate J:211364
decreased ventricle muscle contractility J:211364
enlarged heart J:211364
increased heart weight J:211364
increased myocardial fiber size J:211364
postnatal lethality, incomplete penetrance J:211364
premature death J:211364
prolonged P wave J:211364
prolonged QT interval J:211364
prolonged ST segment J:211364
Wdr1tm1b(EUCOMM)Hmgu/Wdr1tm1b(EUCOMM)Hmgu
C57BL/6N-Wdr1tm1b(EUCOMM)Hmgu/Bay 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory