Cflar Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cflar
CASP8 and FADD-like apoptosis regulator
MGI:1336166

39 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cflar^tm1.1Pope/Cflar^tm1.2Pope Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd	abnormal abdominal lymph node morphology	J:167430
	abnormal B cell number	J:167430
	abnormal bone marrow cell number	J:167430
	abnormal CD4-positive, alpha-beta T cell number	J:167430
	abnormal CD8-positive, alpha-beta T cell number	J:167430
	abnormal definitive hematopoiesis	J:167430
	abnormal erythropoiesis	J:167430
	abnormal lymphocyte cell number	J:167430
	abnormal myelopoiesis	J:167430
	abnormal spleen B cell follicle morphology	J:167430
	abnormal spleen marginal zone morphology	J:167430
	abnormal spleen morphology	J:167430
	abnormal spleen red pulp morphology	J:167430
	abnormal thymus corticomedullary boundary morphology	J:167430
	abnormal thymus morphology	J:167430
	anemia	J:167430
	decreased body size	J:167430
	decreased macrophage cell number	J:167430
	enlarged spleen	J:167430
	increased CD8-positive, alpha-beta T cell number	J:167430
	increased eosinophil cell number	J:167430
	increased granulocyte number	J:167430
	increased leukocyte cell number	J:167430
	increased monocyte cell number	J:167430
	increased neutrophil cell number	J:167430
	premature death	J:167430
	thrombocytosis	J:167430
Cflar^{tm1b(EUCOMM)Wtsi}/Cflar^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cflar^{tm1b(EUCOMM)Wtsi}/Orl	preweaning lethality, complete penetrance	J:211773
Cflar^tm1Mak/Cflar^tm1Mak either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal myocardial trabeculae morphology	J:63049
	delayed heart development	J:63049
	distended pericardium	J:63049
	embryonic growth retardation	J:63049
	embryonic lethality during organogenesis, complete penetrance	J:63049
	hemorrhage	J:63049
	increased fibroblast apoptosis	J:63049
	pericardial edema	J:63049
	thin myocardium	J:63049
Cflar^tm1Ywh/Cflar^tm1Ywh Tg(Lck-cre)548Jxm/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	decreased single-positive T cell number	J:100558
	increased thymocyte apoptosis	J:100558

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23