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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Asah1
N-acylsphingosine amidohydrolase 1
MGI:1277124
76 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Asah1tm1.1Jhkh/Asah1tm1.1Jhkh
Not Specified
abnormal ceramide level J:199833
abnormal depression-related behavior J:199833
abnormal neuron differentiation J:199833
abnormal physiological response to xenobiotic J:199833
Asah1tm1.2Geno/Asah1tm1.2Geno
involves: C57BL/6
abnormal circulating cytokine level J:285931
abnormal gait J:285931
abnormal knee joint morphology J:285931
abnormal lymph node morphology J:285931
abnormal sphingomyelin level J:285931
abnormal thymus morphology J:285931
astrocytosis J:285931
centrally nucleated skeletal muscle fibers J:285931
decreased B cell number J:285931
decreased CD4-positive, alpha-beta T cell number J:285931
decreased CD8-positive, alpha-beta T cell number J:285931
decreased double-positive T cell number J:285931
decreased leukocyte cell number J:285931
decreased lymphocyte cell number J:285931
decreased mean corpuscular hemoglobin J:285931
decreased mean corpuscular volume J:285931
decreased splenocyte number J:285931
decreased T cell number J:285931
dystrophic muscle J:285931
enlarged spleen J:285931
increased blood urea nitrogen level J:285931
increased ceramide level J:285931
increased circulating alanine transaminase level J:285931
increased circulating aspartate transaminase level J:285931
increased circulating creatine kinase level J:285931
increased circulating CXCL10 level J:285931
increased circulating lactate dehydrogenase level J:285931
increased erythrocyte cell number J:285931
increased granulocyte number J:285931
increased hematopoietic stem cell number J:285931
increased macrophage cell number J:285931
increased macrophage derived foam cell number J:285931
increased monocyte cell number J:285931
increased sphingosine level J:285931
liver fibrosis J:285931
lung inflammation J:285931
premature death J:285931
scoliosis J:285931
skeletal muscle fiber atrophy J:285931
weight loss J:285931
Asah1tm1Esc/Asah1+
involves: 129S1/Sv * C57BL/6
abnormal lipid homeostasis J:74647
abnormal liver morphology J:74647
pale liver J:74647
Asah1tm1Esc/Asah1tm1Esc
involves: 129S1/Sv * C57BL/6
embryonic lethality, complete penetrance J:74647
Asah1tm1Medin/Asah1tm1Medin
involves: 129S6/SvEvTac * CD-1
abnormal ceramide level J:232306
abnormal chemokine secretion J:232306
abnormal circulating chemokine level J:232306
abnormal endochondral bone ossification J:232306
abnormal enzyme/coenzyme activity J:232306
abnormal lysosome morphology J:232306
abnormal pulmonary alveolus morphology J:232306
cachexia J:232306
decreased gonadal fat pad weight J:232306
decreased long bone epiphyseal plate size J:232306
decreased tertiary ovarian follicle number J:232306
dilated brain ventricle J:232306
enlarged lymph nodes J:232306
enlarged spleen J:232306
enlarged thymus J:232306
hepatic necrosis J:232306
hydrocephaly J:232306
increased circulating interleukin-12b level J:232306
increased eosinophil cell number J:232306
increased erythrocyte cell number J:232306
increased hemoglobin content J:232306
increased leukocyte cell number J:232306
increased macrophage derived foam cell number J:232306
increased monocyte cell number J:232306
increased neutrophil cell number J:232306
increased spleen weight J:232306
lethargy J:232306
limb grasping J:232306
pale spleen J:232306
penis prolapse J:232306
postnatal growth retardation J:232306
premature death J:232306
pulmonary alveolar edema J:232306
small ovary J:232306
weight loss J:232306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory