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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smad7
SMAD family member 7
MGI:1100518
49 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Smad7Gt(YHC053)Byg/Smad7Gt(YHC053)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal fourth pharyngeal arch artery morphology J:212881
abnormal thymus morphology J:212881
cleft palate J:212881
thymus hypoplasia J:212881
ventricular septal defect J:212881
Smad7tm1.1Ink/Smad7tm1.1Ink
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal T-helper 1 cell differentiation J:184670
decreased activated T cell number J:184670
decreased interferon-gamma secretion J:184670
decreased interleukin-9 secretion J:184670
decreased susceptibility to experimental autoimmune encephalomyelitis J:184670
decreased T cell proliferation J:184670
normal immune system phenotype J:184670
increased transforming growth factor beta level J:184670
paralysis J:184670
Smad7tm1.1Shou/Smad7tm1.1Shou
involves: C57BL/6 * FVB 		abnormal atrioventricular cushion morphology J:145777
abnormal blood circulation J:145777
abnormal cardiovascular development J:145777
abnormal heart development J:145777
abnormal heart ventricle morphology J:145777
abnormal QRS complex J:145777
abnormal trabecula carnea morphology J:145777
decreased body size J:145777
decreased cardiac muscle contractility J:145777
decreased heart right ventricle wall thickness J:145777
irregular heartbeat J:145777
pallor J:145777
preweaning lethality, incomplete penetrance J:145777
prolonged RR interval J:145777
skin edema J:145777
transposition of great arteries J:145777
ventricular septal defect J:145777
Smad7tm1.2Ink/Smad7tm1.2Ink
involves: BALB/cJ * C57BL/6 		preweaning lethality, complete penetrance J:184670
Smad7tm1Gkg/Smad7tm1Gkg
Tg(Pdx1-cre/Esr1*)#Dam/0
involves: C57BL/6 * CBA 		abnormal pancreatic beta cell differentiation J:198451
decreased pancreatic alpha cell number J:198451
decreased pancreatic beta cell number J:198451
Smad7tm1Gkh/Smad7tm1Gkh
B6N.129S6-Smad7tm1Gkh 		no abnormal phenotype detected J:213468
Smad7tm1Gkh/Smad7tm1Gkh
Tg(Cd4-cre)1Cwi/0
B6N.Cg-Tg(CD4-cre)1Cwi Smad7tm1Gkh 		abnormal bone marrow cell physiology J:213468
Smad7tm1Rheu/Smad7tm1Rheu
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal class switch recombination J:120714
decreased B cell proliferation J:120714
decreased birth body size J:120714
decreased body weight J:120714
decreased litter size J:120714
increased B cell apoptosis J:120714
perinatal lethality, incomplete penetrance J:120714
Smad7tm1Shou/Smad7tm1Shou
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 		abnormal atrioventricular cushion morphology J:145777
abnormal blood circulation J:145777
abnormal cardiovascular development J:145777
abnormal heart development J:145777
abnormal heart ventricle morphology J:145777
abnormal QRS complex J:145777
abnormal trabecula carnea morphology J:145777
decreased body size J:145777
decreased cardiac muscle contractility J:145777
decreased heart right ventricle wall thickness J:145777
irregular heartbeat J:145777
pallor J:145777
preweaning lethality, incomplete penetrance J:145777
prolonged RR interval J:145777
skin edema J:145777
transposition of great arteries J:145777
ventricular septal defect J:145777
Tg(Cd2-Smad7)#Chbe/0
involves: C57BL/6 		abnormal T-helper 1 cell differentiation J:184670
decreased interleukin-9 secretion J:184670
decreased interleukin-10 secretion J:184670
decreased interleukin-17 secretion J:184670
decreased transforming growth factor beta level J:184670
increased interferon-gamma secretion J:184670
increased susceptibility to experimental autoimmune encephalomyelitis J:184670
increased susceptibility to induced morbidity/mortality J:184670
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory