Smad7tm1.1Shou
Targeted Allele Detail
|
Symbol: |
Smad7tm1.1Shou |
Name: |
SMAD family member 7; targeted mutation 1.1, Weinian Shou |
MGI ID: |
MGI:3839577 |
Synonyms: |
Smad7deltaMH2 |
Gene: |
Smad7 Location: Chr18:75500600-75529006 bp, + strand Genetic Position: Chr18, 51.06 cM, cytoband E2
|
Alliance: |
Smad7tm1.1Shou page
|
|
Defects of cardiac development in Smad7tm1.1Shou/Smad7tm1.1Shou mice
Show the 4 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:145777
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Germ line, cre mediated recombination removed the 5' portion of exon 4. The entire exon 4 codes for the MH2 domain. RT-PCR confirmed the lack of transcripts containing exon 4.
(J:145777)
|
|
Generation of the Smad7tm1Shou and Smad7tm1.1Shou alleles |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Smad7 Mutation: |
53 strains or lines available
|
|
Original: |
J:145777 Chen Q, et al., Smad7 is required for the development and function of the heart. J Biol Chem. 2009 Jan 2;284(1):292-300 |
All: |
2 reference(s) |
|