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| Caption | Cardiac development defects. A: Under-presentation of Smad7tm1.1Shou/Smad7tm1.1Shou (-/-) mice. The table summarizes the number of mice that survived to weaning stage. B: Summary of cardiac phenotypes of mutant embryos at E14.5 and E16.5. C and D: Embryo images and histological analyses of mutant mice at E14.5 and E16.5. Note that the mutant mice had edema in the dorsal region (marked by *). Transverse heart sections (right panels) at atrioventricular valve level showed a ventricular septal defect (VSD, arrowheads) and ventricular non-compaction (arrows). RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; and VS, ventricular septum. E: Neonatal mutant mouse was smaller and pale in comparison with wild-type (+/+) littermate (left panel). Transverse heart sections (right panel) revealed VSD (arrowhead) and ventricular non-compaction (arrow). F: Outflow tract defects in a mutant mouse. The positioning of aorta (A) relative to pulmonary artery (P) was altered in mutant embryos at E16.5. | ||||
| Copyright | This image is from Chen Q, J Biol Chem 2009 Jan 2;284(1):292-300 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:145777 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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