Phenotypes associated with this allele

• Allele Symbol: Smad7^tm1.1Shou
• Allele Name: targeted mutation 1.1, Weinian Shou
• Allele ID: MGI:3839577
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad7^tm1.1Shou/Smad7^tm1.1Shou	involves: C57BL/6 * FVB	MGI:3839598

Genotype
MGI:3839598

hm1

• Allelic Composition: Smad7^tm1.1Shou/Smad7^tm1.1Shou
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defects of cardiac development in Smad7^tm1.1Shou/Smad7^tm1.1Shou mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:145777 )

• fewer than expected mice survive pre-weaning

cardiovascular system

abnormal cardiovascular development ( J:145777 )

abnormal heart development ( J:145777 )

• developing heart trabecular myocardium and endocardium proliferation is increased compared to in wild-type mice

abnormal atrioventricular cushion morphology ( J:145777 )

• at E14.5, apoptosis in the atrioventricular cushion is increased compared to in wild-type mice

transposition of great arteries ( J:145777 )

abnormal heart ventricle morphology ( J:145777 )

• mice exhibit ventricular non-compaction unlike in wild-type mice

abnormal trabecula carnea morphology ( J:145777 )

• the right ventricle trabecular area is increased compared to in wild-type mice

ventricular septal defect ( J:145777 )

decreased heart right ventricle wall thickness ( J:145777 )

• thin right ventricle wall

abnormal blood circulation ( J:145777 )

• mice exhibit an increase in systolic ventricular chamber volume compared to in wild-type mice

decreased cardiac muscle contractility ( J:145777 )

• mice exhibit decreased fractional shortening and ejection fraction compared to wild-type mice

prolonged RR interval ( J:145777 )

• the R-R interval is increased compared to in wild-type mice

irregular heartbeat ( J:145777 )

• mice exhibit arrhythmias

abnormal QRS complex ( J:145777 )

• although the QRS duration is normal, the QRS complex exhibits morphological abnormalities compared to in wild-type mice

growth/size/body

decreased body size ( J:145777 )

• neonatally

muscle

abnormal trabecula carnea morphology ( J:145777 )

• the right ventricle trabecular area is increased compared to in wild-type mice

decreased cardiac muscle contractility ( J:145777 )

• mice exhibit decreased fractional shortening and ejection fraction compared to wild-type mice

homeostasis/metabolism

skin edema ( J:145777 )

• at E14.5 and E16.5

integument

skin edema ( J:145777 )

• at E14.5 and E16.5

pallor ( J:145777 )

• mice are pale at E14.5, E16.5, and after birth