Pkn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pkn2
protein kinase N2
MGI:109211

42 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Pkn2^{tm1c(KOMP)Wtsi}/Pkn2^{tm1c(KOMP)Wtsi} involves: C57BL/6N * C57BL/6NTac	abnormal embryo morphology	J:229595
	abnormal embryo turning	J:229595
	abnormal mesenchyme morphology	J:229595
	abnormal mesoderm morphology	J:229595
	abnormal mitosis	J:229595
	abnormal vascular development	J:229595
	absent pharyngeal arches	J:229595
	decreased fibroblast proliferation	J:229595
	decreased mitotic index	J:229595
	hemorrhage	J:229595
	increased embryonic tissue cell apoptosis	J:229595
Pkn2^{tm1a(KOMP)Wtsi}/Pkn2^{tm1a(KOMP)Wtsi} involves: C57BL/6N	abnormal developmental patterning	J:229595
	abnormal embryo turning	J:229595
	abnormal fibroblast proliferation	J:229595
	abnormal germ layer morphology	J:229595
	abnormal head development	J:229595
	abnormal mesenchyme morphology	J:229595
	abnormal neural crest cell migration	J:229595
	abnormal neural fold formation	J:229595
	abnormal neural tube morphology	J:229595
	abnormal rostral-caudal body axis extension	J:229595
	abnormal somite development	J:229595
	abnormal vascular development	J:229595
	abnormal vascular plexus formation	J:229595
	abnormal vitelline vasculature morphology	J:229595
	absent pharyngeal arches	J:229595
	absent vitelline blood vessels	J:229595
	craniorachischisis	J:229595
	delayed heart looping	J:229595
	disorganized yolk sac vascular plexus	J:229595
	embryonic lethality during organogenesis, complete penetrance	J:229595
	open neural tube	J:229595
	pericardial edema	J:229595
Pkn2^{tm1b(KOMP)Wtsi}/Pkn2⁺ C57BL/6N-Pkn2^{tm1b(KOMP)Wtsi}/Ieg	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating total protein level	J:211773
	decreased circulating unsaturated transferrin level	J:211773
	decreased exploration in new environment	J:211773
	increased circulating bilirubin level	J:211773
	increased startle reflex	J:211773
Pkn2^{tm1b(KOMP)Wtsi}/Pkn2^{tm1b(KOMP)Wtsi} C57BL/6N-Pkn2^{tm1b(KOMP)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Pkn2^{tm1c(KOMP)Wtsi}/Pkn2^{tm1c(KOMP)Wtsi} Tg(Tagln-cre)1Jjl/0 involves: C57BL/6N * FVB/N	cardiac hypertrophy	J:229595
	lethality, incomplete penetrance	J:229595
	overexpanded pulmonary alveolus	J:229595
	pulmonary fibrosis	J:229595
Pkn2^{tm1c(KOMP)Wtsi}/Pkn2^{tm1c(KOMP)Wtsi} Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:229595

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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