Lig3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lig3
ligase III, DNA, ATP-dependent
MGI:109152

28 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lig3^tm1.1Pmc/Lig3^tm1.1Pmc Tg(Ckmm-cre)5Khn/0 involves: C57BL/6 * FVB	abnormal cardiovascular system physiology	J:170077
	abnormal myocardial fiber morphology	J:170077
	decreased cardiac muscle contractility	J:170077
	dilated heart atrium	J:170077
	dilated heart ventricle	J:170077
	enlarged heart	J:170077
	premature death	J:170077
	thin ventricular wall	J:170077
Lig3^tm1.1Pmc/Lig3^tm1.1Pmc Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal astrocyte morphology	J:170077
	abnormal astrocyte physiology	J:170077
	abnormal cellular respiration	J:170077
	abnormal cerebellum development	J:170077
	abnormal DNA repair	J:170077
	abnormal neuron differentiation	J:170077
	abnormal neuronal precursor proliferation	J:170077
	ataxia	J:170077
	decreased brain size	J:170077
	decreased cerebellar granule cell number	J:170077
	decreased oligodendrocyte number	J:170077
	microcephaly	J:170077
	postnatal growth retardation	J:170077
	postnatal lethality, complete penetrance	J:170077
	small cerebellum	J:170077
Lig3^tm1Czhu/Lig3^tm1Czhu involves: 129	decreased embryo size	J:109063
	elevated level of mitotic sister chromatid exchange	J:109063
	embryonic growth retardation	J:109063
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:109063
	embryonic lethality between somite formation and embryo turning, incomplete penetrance	J:109063

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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