Hrh1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hrh1
histamine receptor H1
MGI:107619

38 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hrh1^Bphs-r/Hrh1^Bphs-r C3H/HeJ	normal immune system phenotype	J:4933, J:77938
Hrh1^Bphs-r/Hrh1^Bphs-s (C3H/HeJ x SJL/J)F1	abnormal immune system physiology	J:77938
	abnormal response to infection	J:77938
	increased susceptibility to bacterial infection	J:77938
	increased susceptibility to bacterial infection induced morbidity/mortality	J:77938
Hrh1^Bphs-s/Hrh1^Bphs-s C3.SJL-Hrh1^Bphs-s	abnormal response to infection	J:77938
	increased susceptibility to bacterial infection	J:77938
	increased susceptibility to bacterial infection induced morbidity/mortality	J:77938
Hrh1^{em1(IMPC)Rbrc}/Hrh1^{em1(IMPC)Rbrc} C57BL/6NJcl-Hrh1^{em1(IMPC)Rbrc}/Rbrc	abnormal kidney morphology	J:211773
Hrh1^tm1Wtn/Hrh1^tm1Wtn B6.129P2-Hrh1^tm1Wtn	abnormal circadian feeding behavior	J:107191
	abnormal response/metabolism to endogenous compounds	J:107191
	decreased body weight	J:107191
	decreased circulating insulin level	J:107191
	decreased food intake	J:107191
	decreased inflammatory response	J:110367
	decreased interferon-gamma secretion	J:110367
	decreased interleukin-5 secretion	J:110367
	decreased interleukin-13 secretion	J:110367
	decreased total body fat amount	J:107191
	increased body weight	J:107191
	increased brown adipose tissue amount	J:107191
	increased circulating free fatty acids level	J:107191
	increased circulating leptin level	J:107191
	increased fat cell size	J:107191
	increased food intake	J:107191
	increased IgG level	J:110367
	increased IgM level	J:110367
	increased liver triglyceride level	J:107191
	increased skeletal muscle triglyceride level	J:107191
	increased white adipose tissue amount	J:107191
Hrh1^tm1Wtn/Hrh1^tm1Wtn involves: 129P2/OlaHsd * C57BL/6	abnormal behavior	J:36556
	abnormal locomotor circadian rhythm	J:36556
	decreased B cell proliferation	J:111704
	decreased exploration in new environment	J:36556
	decreased IgG3 level	J:111704
	decreased IgM level	J:111704
	decreased interferon-gamma secretion	J:111704
	decreased interleukin-2 secretion	J:111704
	decreased T cell number	J:111704
	decreased T cell proliferation	J:111704
	decreased vertical activity	J:36556
	increased interleukin-4 secretion	J:111704

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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