42 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dvl1tm1Awb/Dvl1+ Dvl2tm1Awb/Dvl2+ involves: 129S6/SvEvTac	normal hearing/vestibular/ear phenotype	J:100861
Dvl1tm1Awb/Dvl1+ Dvl2tm1Awb/Dvl2tm1Awb involves: 129S6/SvEvTac * LPT/LeJ	neonatal lethality, incomplete penetrance	J:108512
Dvl1tm1Awb/Dvl1+ Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	craniorachischisis	J:108512
	neonatal lethality, complete penetrance	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)	abnormal organ of Corti morphology	J:100861
	abnormal orientation of outer hair cell stereociliary bundles	J:100861
	abnormal somite development	J:79834
	abnormal vertebrae morphology	J:79834
	double outlet right ventricle	J:79834
	exencephaly	J:79834
	increased cochlear hair cell number	J:100861
	open neural tube	J:79834
	persistent truncus arteriosus	J:79834
	prenatal lethality, complete penetrance	J:79834
	rib fusion	J:79834
	transposition of great arteries	J:79834
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb involves: 129S6/SvEvTac	abnormal cochlear inner hair cell morphology	J:108512
	abnormal embryo development	J:108512
	abnormal notochord morphology	J:108512
	abnormal orientation of outer hair cell stereociliary bundles	J:108512
	enlarged floor plate	J:108512
	open neural tube	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb involves: 129S6/SvEvTac * C57BL/6	normal hearing/vestibular/ear phenotype	J:108512
	open neural tube	J:108512
	premature death	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2*/EGFP)3Awb/? involves: 129S6/SvEvTac	normal nervous system phenotype	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2*/EGFP)4Awb/? involves: 129S6/SvEvTac	craniorachischisis	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2*K446M/EGFP)5Awb/? involves: 129S6/SvEvTac	abnormal cochlea morphology	J:108512
	abnormal orientation of outer hair cell stereociliary bundles	J:108512
	craniorachischisis	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2/EGFP)1Awb/? involves: 129S6/SvEvTac	no abnormal phenotype detected	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2/EGFP)2Awb/? involves: 129S6/SvEvTac	no abnormal phenotype detected	J:108512
Dvl1tm1Awb/Dvl1tm1Awb Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2Lp involves: 129S6/SvEvTac * LPT/LeJ	craniorachischisis	J:108512
Dvl2tm1.2Wds/Dvl2+ Shroom3Gt(ROSA53)Sor/Shroom3+ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	abnormal heart morphology	J:293794
	double outlet right ventricle	J:293794
	perimembraneous ventricular septal defect	J:293794
Dvl2tm1.2Wds/Dvl2+ Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	transmission ratio distortion	J:293794
Dvl2tm1.2Wds/Dvl2tm1.2Wds Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	transmission ratio distortion	J:293794
Dvl2tm1Awb/Dvl2+ Dvl3tm1Awb/Dvl3+ involves: 129S6/SvEvTac * Black Swiss	abnormal cardiac outflow tract development	J:142392
	abnormal orientation of cochlear hair cell stereociliary bundles	J:142392
	double outlet right ventricle	J:142392
	persistent truncus arteriosus	J:142392
	transposition of great arteries	J:142392
Dvl2tm1Awb/Dvl2+ Dvl3tm1Awb/Dvl3tm1Awb involves: 129S6/SvEvTac * Black Swiss	abnormal head morphology	J:142392
	abnormal heart shape	J:142392
	abnormal orientation of cochlear hair cell stereociliary bundles	J:142392
	absent tail	J:142392
	craniorachischisis	J:142392
	herniated abdominal wall	J:142392
	kinked tail	J:142392
	persistent truncus arteriosus	J:142392
	short rostral-caudal axis	J:142392
	short snout	J:142392
	short tail	J:142392
	small heart	J:142392
Dvl2tm1Awb/Dvl2tm1Awb Dvl3tm1Awb/Dvl3+ involves: 129S6/SvEvTac * Black Swiss	abnormal heart looping	J:142392
	caudal body truncation	J:142392
	craniorachischisis	J:142392
	embryonic lethality, complete penetrance	J:142392
	pericardial effusion	J:142392
Dvl2tm1Awb/Dvl2tm1Awb Dvl3tm1Awb/Dvl3tm1Awb involves: 129S6/SvEvTac * Black Swiss	embryonic lethality, complete penetrance	J:142392
Dvl2tm1Awb/Dvl2tm1Awb Tg(Dvl2/EGFP)2Awb/? Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	no abnormal phenotype detected	J:108512
Dvl2tm1Awb/Dvl2tm1Awb Vangl2Lp/Vangl2+ involves: 129S6/SvEvTac * LPT/LeJ	abnormal cochlear inner hair cell morphology	J:108512
	abnormal embryo development	J:108512
	abnormal organ of Corti morphology	J:100861
	abnormal orientation of cochlear hair cell stereociliary bundles	J:100861
	craniorachischisis	J:108512
	increased cochlear hair cell number	J:100861
	neonatal lethality, complete penetrance	J:108512
Vangl2Lp/Vangl2Lp Tg(Dvl2/EGFP)2Awb/? involves: LPT/LeJ	abnormal organ of Corti morphology	J:100861