About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pms2
PMS1 homolog2, mismatch repair system component
MGI:104288
16 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Pms2tm1Lisk/Pms2tm1Lisk
involves: 129S2/SvPas * C57BL/6J 		increased intestinal adenoma incidence J:46419
intestine polyps J:46419
premature death J:46419
Apctm1Rak/Apc+
Pms2tm1.1Sks/Pms2tm1.1Sks
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J 		intestine polyps J:310354
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
involves: 129S4/SvJae * 129S4/SvJaeSor 		abnormal mismatch repair J:204653
increased lung tumor incidence J:204653
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
involves: 129S4/SvJaeSor 		abnormal mismatch repair J:204653
Pms2tm1Lisk/Pms2tm1Lisk
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL 		abnormal cell physiology J:125218
abnormal DNA repair J:125218
abnormal intestine morphology J:125218
chromosomal instability J:125218
decreased telomere length J:125218
normal digestive/alimentary phenotype J:125218
increased carcinoma incidence J:125218
increased enterocyte apoptosis J:125218
increased lymphoma incidence J:125218
increased sarcoma incidence J:125218
normal mortality/aging J:125218
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory