Ppp5c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp5c
protein phosphatase 5, catalytic subunit
MGI:102666

34 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppp5c^Gt(XG029)Byg/Ppp5c^Gt(XG029)Byg involves: 129P2/OlaHsd * C57BL/6J	abnormal cell cycle checkpoint function	J:122564
Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon B6.129X1-Ppp5c^tm1.2Rhon	abnormal cell adhesion	J:178164
	abnormal cell morphology	J:178164
	decreased body weight	J:178164
	decreased fibroblast proliferation	J:178164
	decreased litter size	J:178164
	enlarged spleen	J:178164
	lethality, incomplete penetrance	J:178164
Ppp5c^tm1.2Rhon/Ppp5c^tm1.2Rhon either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J * FVB/N)	no abnormal phenotype detected	J:178164
Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi} B6Dnk;B6Brd;B6N-Ppp5c^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH	abnormal behavior	J:175295
	abnormal bone structure	J:175295
	abnormal coat/hair pigmentation	J:175295
	abnormal rib morphology	J:165965, J:175295
	decreased body length	J:165965, J:175295
	decreased body weight	J:165965, J:175295
	decreased circulating cholesterol level	J:175295
	decreased circulating glucose level	J:175295
	decreased circulating HDL cholesterol level	J:175295
	decreased circulating triglyceride level	J:175295
	decreased lumbar vertebrae number	J:165965, J:175295
	decreased mean corpuscular hemoglobin concentration	J:175295
	decreased rib number	J:165965, J:175295
	decreased thoracic vertebrae number	J:165965
	vertebral fusion	J:165965
Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N	abnormal rib morphology	J:213427
	caudal vertebral fusion	J:213427
	caudal vertebral transformation	J:213427
	cervical vertebral fusion	J:213427
	decreased body length	J:213427
	decreased body weight	J:213427
	decreased lumbar vertebrae number	J:213427
	decreased respiratory quotient	J:213427
	decreased rib number	J:213427
	decreased thoracic vertebrae number	J:213427
	increased CD4-positive, alpha-beta T cell number	J:213427
	increased CD8-positive, alpha-beta T cell number	J:213427
	increased lymphoma incidence	J:213427
	increased T cell number	J:213427
	lymphoid hyperplasia	J:213427
	truncated ribs	J:213427
	vertebral fusion	J:213427
	vertebral transformation	J:213427
Ppp5c^tm1Lex/Ppp5c^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:103485

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23