Ppp5c^tm1.2Rhon
Targeted Allele Detail

Summary

• Symbol: Ppp5c^tm1.2Rhon
• Name: protein phosphatase 5, catalytic subunit; targeted mutation 1.2, Richard E Honkanen
• MGI ID: MGI:5301885
• Gene: Ppp5c Location: Chr7:16738575-16761812 bp, - strand Genetic Position: Chr7, 9.15 cM
• Alliance: Ppp5c^tm1.2Rhon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178164
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Ppp5a^tm1.1Rhon removed exon 1 and left the EGFP gene intact. Western blot analysis confirmed the absence of protein expression in stomach, liver, and kidney. (J:178164)

Generation of the Ppp5c^tm1.1Rhon and Ppp5c^tm1.2Rhon alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp5c Mutation: 46 strains or lines available

Notes

ES cell line = 129/X1A from Yale Animal Genomics (J:178164).

References

• Original: J:178164 Amable L, et al., Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1). J Biol Chem. 2011 Nov 25;286(47):40413-22
• All: 4 reference(s)