GO Annotations Graph

• Symbol: Rara
• Name: retinoic acid receptor, alpha
• ID: MGI:97856

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:88316
Molecular Function	GO:0003677	DNA binding	IDA	J:96448
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:17599
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:96448
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0048027	mRNA 5'-UTR binding	ISO	J:155856
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:96448
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:94471
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:178274
Molecular Function	GO:0005515	protein binding	IPI	J:266112
Molecular Function	GO:0005515	protein binding	IPI	J:113776
Molecular Function	GO:0005515	protein binding	IPI	J:154929
Molecular Function	GO:0005515	protein binding	IPI	J:144224
Molecular Function	GO:0005515	protein binding	IPI	J:178277
Molecular Function	GO:0005515	protein binding	IPI	J:37212
Molecular Function	GO:0005515	protein binding	IPI	J:78275
Molecular Function	GO:0005515	protein binding	IPI	J:63034
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0051018	protein kinase A binding	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:164563
Molecular Function	GO:0001972	retinoic acid binding	ISO	J:164563
Molecular Function	GO:0044323	retinoic acid-responsive element binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:200642
Molecular Function	GO:0043565	sequence-specific DNA binding	IGI	J:22384
Molecular Function	GO:0043565	sequence-specific DNA binding	IGI	J:22384
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:127720
Molecular Function	GO:0043565	sequence-specific DNA binding	IGI	J:22384
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IMP	J:154929
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:217510
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	IPI	J:178274
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:77521
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617960
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619411
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619434
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5693628
Cellular Component	GO:0005634	nucleus	IDA	J:154929
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:77521
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NAS	J:45674
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:314562
Cellular Component	GO:0005667	transcription regulator complex	EXP	J:320125
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0060348	bone development	IGI	J:42773
Biological Process	GO:0060348	bone development	IGI	J:21009
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071391	cellular response to estrogen stimulus	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:154929
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:164563
Biological Process	GO:0060591	chondroblast differentiation	IMP	J:60610
Biological Process	GO:0031076	embryonic camera-type eye development	IGI	J:21009
Biological Process	GO:0060324	face development	IGI	J:21009
Biological Process	GO:0007281	germ cell development	IMP	J:98529
Biological Process	GO:0002068	glandular epithelial cell development	IGI	J:21009
Biological Process	GO:0002068	glandular epithelial cell development	IGI	J:21009
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:149466
Biological Process	GO:0009755	hormone-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0060173	limb development	IGI	J:21009
Biological Process	GO:0008584	male gonad development	ISO	J:155856
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	NAS	J:45674
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0035264	multicellular organism growth	IGI	J:149466
Biological Process	GO:0061037	negative regulation of cartilage development	IMP	J:60610
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:60610
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:72326
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:72326
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:130210
Biological Process	GO:0030853	negative regulation of granulocyte differentiation	ISO	J:164563
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:29044
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:17599
Biological Process	GO:0017148	negative regulation of translation	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IGI	J:21009
Biological Process	GO:0051099	positive regulation of binding	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:130210
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:154929
Biological Process	GO:0032736	positive regulation of interleukin-13 production	ISO	J:164563
Biological Process	GO:0032753	positive regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0032754	positive regulation of interleukin-5 production	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:22384
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:200642
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:22384
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:22384
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:78275
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:94471
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:77521
Biological Process	GO:0030852	regulation of granulocyte differentiation	IMP	J:67762
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	IMP	J:67762
Biological Process	GO:0031641	regulation of myelination	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0032526	response to retinoic acid	ISO	J:164563
Biological Process	GO:0032526	response to retinoic acid	IMP	J:67762
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IBA	J:265628
Biological Process	GO:0060010	Sertoli cell fate commitment	IMP	J:175162
Biological Process	GO:0060534	trachea cartilage development	IMP	J:42773
Biological Process	GO:0001657	ureteric bud development	IMP	J:78712
Biological Process	GO:0055012	ventricular cardiac muscle cell differentiation	IMP	J:44836