Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor activity; and transcription coactivator binding activity. Involved in several processes, including Sertoli cell fate commitment; cellular response to lipopolysaccharide; and germ cell development. Acts upstream of or within several processes, including cartilage development; negative regulation of cartilage development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha).