Pax6 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pax6
paired box 6
MGI:97490

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:206724
Molecular Function	GO:0003682	chromatin binding	IDA	J:145977
Molecular Function	GO:0003682	chromatin binding	IDA	J:197144
Molecular Function	GO:0003682	chromatin binding	IDA	J:197144
Molecular Function	GO:0003682	chromatin binding	IDA	J:197144
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:266522
Molecular Function	GO:0070410	co-SMAD binding	IDA	J:172985
Molecular Function	GO:0003677	DNA binding	IDA	J:83532
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:83532
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:178696
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:178696
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:54357
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:133921
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:170025
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:180474
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:197897
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0035035	histone acetyltransferase binding	IDA	J:180474
Molecular Function	GO:0071837	HMG box domain binding	IPI	J:175179
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:297319
Molecular Function	GO:0005515	protein binding	IPI	J:108784
Molecular Function	GO:0005515	protein binding	IPI	J:167158
Molecular Function	GO:0005515	protein binding	IPI	J:114731
Molecular Function	GO:0005515	protein binding	IPI	J:196061
Molecular Function	GO:0005515	protein binding	IPI	J:114731
Molecular Function	GO:0005515	protein binding	IPI	J:114731
Molecular Function	GO:0005515	protein binding	IPI	J:114731
Molecular Function	GO:0019901	protein kinase binding	IPI	J:180474
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	IDA	J:172985
Molecular Function	GO:0003723	RNA binding	IDA	J:206724
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:83532
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:170025
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	J:180474
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:197897
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:297319
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:149737
Molecular Function	GO:0001221	transcription coregulator binding	IPI	J:180474
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:137611
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	IDA	J:170025
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:105207
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:297319
Cellular Component	GO:0005634	nucleus	IDA	J:74097
Cellular Component	GO:0005634	nucleus	IDA	J:77680
Cellular Component	GO:0005634	nucleus	IDA	J:212720
Cellular Component	GO:0005634	nucleus	IDA	J:74097
Cellular Component	GO:0005634	nucleus	IDA	J:109412
Cellular Component	GO:0005634	nucleus	IDA	J:41620
Cellular Component	GO:0005634	nucleus	IDA	J:197573
Cellular Component	GO:0005634	nucleus	IDA	J:187631
Cellular Component	GO:0005634	nucleus	IDA	J:86636
Cellular Component	GO:0005634	nucleus	IDA	J:150768
Cellular Component	GO:0005634	nucleus	IDA	J:74097
Cellular Component	GO:0005634	nucleus	IDA	J:215584
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:54357
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:98539
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:78745
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:98539
Biological Process	GO:0048708	astrocyte differentiation	ISO	J:155856
Biological Process	GO:0048708	astrocyte differentiation	IMP	J:266522
Biological Process	GO:0048708	astrocyte differentiation	IMP	J:147382
Biological Process	GO:0007411	axon guidance	IMP	J:76341
Biological Process	GO:0007411	axon guidance	IMP	J:86369
Biological Process	GO:0007409	axonogenesis	IMP	J:94588
Biological Process	GO:0007409	axonogenesis	IMP	J:94588
Biological Process	GO:0001568	blood vessel development	ISO	J:164563
Biological Process	GO:0007420	brain development	ISO	J:155856
Biological Process	GO:0007420	brain development	IMP	J:78745
Biological Process	GO:0007420	brain development	IMP	J:54722
Biological Process	GO:0043010	camera-type eye development	IGI	J:78468
Biological Process	GO:0043010	camera-type eye development	IMP	J:65765
Biological Process	GO:0043010	camera-type eye development	IMP	J:66649
Biological Process	GO:0043010	camera-type eye development	IMP	J:99962
Biological Process	GO:0043010	camera-type eye development	IGI	J:77351
Biological Process	GO:0043010	camera-type eye development	IMP	J:82632
Biological Process	GO:0043010	camera-type eye development	IMP	J:83532
Biological Process	GO:0030154	cell differentiation	IMP	J:92173
Biological Process	GO:0030154	cell differentiation	IMP	J:224508
Biological Process	GO:0045165	cell fate commitment	IMP	J:99239
Biological Process	GO:0045165	cell fate commitment	IGI	J:93057
Biological Process	GO:0001709	cell fate determination	IMP	J:83532
Biological Process	GO:0008283	cell population proliferation	IMP	J:94457
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0021987	cerebral cortex development	IMP	J:266522
Biological Process	GO:0021796	cerebral cortex regionalization	IMP	J:266522
Biological Process	GO:0021796	cerebral cortex regionalization	IMP	J:102092
Biological Process	GO:0021796	cerebral cortex regionalization	IMP	J:196080
Biological Process	GO:0006338	chromatin remodeling	IMP	J:266522
Biological Process	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain	IMP	J:66590
Biological Process	GO:0061303	cornea development in camera-type eye	ISO	J:164563
Biological Process	GO:0080111	DNA demethylation	IMP	J:266522
Biological Process	GO:0006306	DNA methylation	IMP	J:266522
Biological Process	GO:0009950	dorsal/ventral axis specification	IMP	J:58952
Biological Process	GO:0009950	dorsal/ventral axis specification	IMP	J:58952
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:94457
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:94457
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:99239
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:94457
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IGI	J:139006
Biological Process	GO:0002064	epithelial cell development	ISO	J:155856
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IMP	J:178696
Biological Process	GO:0042462	eye photoreceptor cell development	IMP	J:82632
Biological Process	GO:0030900	forebrain development	IMP	J:98620
Biological Process	GO:0030900	forebrain development	IMP	J:94588
Biological Process	GO:0030900	forebrain development	IMP	J:98620
Biological Process	GO:0030900	forebrain development	IMP	J:94457
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:66590
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:65195
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:224508
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	IMP	J:146695
Biological Process	GO:0021905	forebrain-midbrain boundary formation	IMP	J:41030
Biological Process	GO:0021905	forebrain-midbrain boundary formation	IMP	J:41030
Biological Process	GO:0010467	gene expression	IMP	J:206724
Biological Process	GO:0010467	gene expression	IMP	J:266522
Biological Process	GO:0002067	glandular epithelial cell differentiation	IMP	J:99962
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0021986	habenula development	IMP	J:224508
Biological Process	GO:0030902	hindbrain development	ISO	J:155856
Biological Process	GO:1901142	insulin metabolic process	ISO	J:155856
Biological Process	GO:0022027	interkinetic nuclear migration	ISO	J:155856
Biological Process	GO:0061072	iris morphogenesis	ISO	J:164563
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:99962
Biological Process	GO:0032808	lacrimal gland development	IMP	J:62162
Biological Process	GO:0098598	learned vocalization behavior or vocal learning	ISO	J:155856
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:21950
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:99962
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:197897
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	IMP	J:94457
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:112802
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:107897
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:297319
Biological Process	GO:0001755	neural crest cell migration	ISO	J:155856
Biological Process	GO:0061351	neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0061351	neural precursor cell proliferation	IMP	J:197897
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:133921
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:94457
Biological Process	GO:0030182	neuron differentiation	IMP	J:266522
Biological Process	GO:0030182	neuron differentiation	IGI	J:112802
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0001764	neuron migration	IMP	J:266522
Biological Process	GO:0001764	neuron migration	IMP	J:98620
Biological Process	GO:0021772	olfactory bulb development	ISO	J:155856
Biological Process	GO:0061034	olfactory bulb mitral cell layer development	ISO	J:155856
Biological Process	GO:0021778	oligodendrocyte cell fate specification	IMP	J:50974
Biological Process	GO:0021543	pallium development	IMP	J:66590
Biological Process	GO:0003322	pancreatic A cell development	IMP	J:170025
Biological Process	GO:0003322	pancreatic A cell development	ISO	J:155856
Biological Process	GO:0003322	pancreatic A cell development	ISO	J:164563
Biological Process	GO:0003310	pancreatic A cell differentiation	ISO	J:155856
Biological Process	GO:0021983	pituitary gland development	IMP	J:58952
Biological Process	GO:0021983	pituitary gland development	IMP	J:58952
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0042660	positive regulation of cell fate specification	ISO	J:155856
Biological Process	GO:1904798	positive regulation of core promoter binding	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:170025
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	IMP	J:99962
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:170025
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0070094	positive regulation of glucagon secretion	ISO	J:155856
Biological Process	GO:0120008	positive regulation of glutamatergic neuron differentiation	ISO	J:155856
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:133921
Biological Process	GO:2001224	positive regulation of neuron migration	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:180474
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:83532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:170025
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:98488
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:197141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:133921
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:154645
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:145977
Biological Process	GO:0033365	protein localization to organelle	IMP	J:103131
Biological Process	GO:0006468	protein phosphorylation	IMP	J:107897
Biological Process	GO:0006468	protein phosphorylation	IMP	J:107897
Biological Process	GO:0003002	regionalization	IMP	J:41030
Biological Process	GO:0003002	regionalization	IMP	J:41030
Biological Process	GO:0003002	regionalization	IMP	J:224508
Biological Process	GO:0009786	regulation of asymmetric cell division	IMP	J:178696
Biological Process	GO:0030334	regulation of cell migration	IMP	J:54722
Biological Process	GO:0030334	regulation of cell migration	IMP	J:146695
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:54357
Biological Process	GO:0010468	regulation of gene expression	IMP	J:116586
Biological Process	GO:0010468	regulation of gene expression	IMP	J:116586
Biological Process	GO:0010468	regulation of gene expression	IMP	J:102092
Biological Process	GO:0010468	regulation of gene expression	IMP	J:116586
Biological Process	GO:0010468	regulation of gene expression	IMP	J:116586
Biological Process	GO:0010468	regulation of gene expression	IMP	J:116586
Biological Process	GO:0010468	regulation of gene expression	IMP	J:142755
Biological Process	GO:0050767	regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:94457
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:94457
Biological Process	GO:0010975	regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0048505	regulation of timing of cell differentiation	IMP	J:50974
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:41620
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:41620
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:41620
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:149737
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:41620
Biological Process	GO:0060041	retina development in camera-type eye	IGI	J:145977
Biological Process	GO:0021593	rhombomere morphogenesis	ISO	J:155856
Biological Process	GO:0007435	salivary gland morphogenesis	IMP	J:74539
Biological Process	GO:1904937	sensory neuron migration	ISO	J:155856
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IDA	J:155850
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:138713
Biological Process	GO:0021978	telencephalon regionalization	IMP	J:146695
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:197141
Biological Process	GO:0003309	type B pancreatic cell differentiation	ISO	J:155856
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:187631
Biological Process	GO:0021517	ventral spinal cord development	IMP	J:164670

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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