GO Annotations Graph

• Symbol: Notch1
• Name: notch 1
• ID: MGI:97363

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Wed Mar 2 12:11:24 2016.

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	IDA	J:97176
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:123632
Molecular Function	GO:0001047	core promoter binding	IDA	J:166398
Molecular Function	GO:0019899	enzyme binding	IPI	J:183220
Molecular Function	GO:0019899	enzyme binding	IPI	J:183961
Molecular Function	GO:0004857	enzyme inhibitor activity	IDA	J:183220
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005112	Notch binding	IPI	J:212472
Molecular Function	GO:0005515	protein binding	IPI	J:225486
Molecular Function	GO:0005515	protein binding	IPI	J:42994
Molecular Function	GO:0005515	protein binding	IPI	J:34426
Molecular Function	GO:0005515	protein binding	IPI	J:208850
Molecular Function	GO:0005515	protein binding	IPI	J:88030
Molecular Function	GO:0005515	protein binding	IPI	J:224744
Molecular Function	GO:0005515	protein binding	IPI	J:180704
Molecular Function	GO:0005515	protein binding	IPI	J:224738
Molecular Function	GO:0005515	protein binding	IPI	J:58381
Molecular Function	GO:0005515	protein binding	IPI	J:166398
Molecular Function	GO:0005515	protein binding	IPI	J:181926
Molecular Function	GO:0005515	protein binding	IPI	J:200507
Molecular Function	GO:0005515	protein binding	IPI	J:97329
Molecular Function	GO:0005515	protein binding	IPI	J:225486
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:212472
Molecular Function	GO:0004872	receptor activity	IEA	J:72247
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:123632
Molecular Function	GO:0003700	transcription factor activity, sequence-specific DNA binding	IDA	J:40289
Molecular Function	GO:0003700	transcription factor activity, sequence-specific DNA binding	IDA	J:123632
Molecular Function	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	IDA	J:119151
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	IDA	J:208850
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:208850
Cellular Component	GO:0071944	cell periphery	IDA	J:195630
Cellular Component	GO:0009986	cell surface	IDA	J:97329
Cellular Component	GO:0005737	cytoplasm	IDA	J:99826
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:212472
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:212472
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016021	integral component of membrane	IEA	J:72247
Cellular Component	GO:0016021	integral component of membrane	IEA	J:60000
Cellular Component	GO:0005887	integral component of plasma membrane	IC	J:58381
Cellular Component	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:54336
Cellular Component	GO:0005634	nucleus	IMP	J:170885
Cellular Component	GO:0005634	nucleus	IDA	J:119151
Cellular Component	GO:0005634	nucleus	IDA	J:183961
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:108824
Cellular Component	GO:0005634	nucleus	IDA	J:225486
Cellular Component	GO:0005634	nucleus	IDA	J:124179
Cellular Component	GO:0005634	nucleus	IDA	J:104840
Cellular Component	GO:0005886	plasma membrane	IDA	J:212472
Cellular Component	GO:0005886	plasma membrane	IDA	J:114702
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0042640	anagen	IMP	J:100563
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0003180	aortic valve morphogenesis	ISO	J:164563
Biological Process	GO:1902263	apoptotic process involved in embryonic digit morphogenesis	IMP	J:102852
Biological Process	GO:0060842	arterial endothelial cell differentiation	IMP	J:89444
Biological Process	GO:0048708	astrocyte differentiation	ISO	J:155856
Biological Process	GO:0003162	atrioventricular node development	IMP	J:171825
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:87765
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:171825
Biological Process	GO:0009912	auditory receptor cell fate commitment	IMP	J:144981
Biological Process	GO:0007409	axonogenesis	IDA	J:95688
Biological Process	GO:0007409	axonogenesis	IMP	J:101735
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:96080
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:165329
Biological Process	GO:0003207	cardiac chamber formation	IMP	J:165329
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IMP	J:133699
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	IMP	J:165329
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:178290
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	IMP	J:170885
Biological Process	GO:0003213	cardiac right atrium morphogenesis	IMP	J:170885
Biological Process	GO:0003219	cardiac right ventricle formation	IMP	J:158135
Biological Process	GO:0060411	cardiac septum morphogenesis	IMP	J:170885
Biological Process	GO:0060948	cardiac vascular smooth muscle cell development	IMP	J:178290
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:178290
Biological Process	GO:0030154	cell differentiation	IMP	J:78726
Biological Process	GO:0030154	cell differentiation	IMP	J:86975
Biological Process	GO:0045165	cell fate commitment	IMP	J:101154
Biological Process	GO:0001708	cell fate specification	IMP	J:90057
Biological Process	GO:0003273	cell migration involved in endocardial cushion formation	IMP	J:165329
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0007386	compartment pattern specification	IMP	J:77247
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:178290
Biological Process	GO:0003169	coronary vein morphogenesis	IMP	J:178290
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:83358
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:25248
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:102852
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:103603
Biological Process	GO:0060956	endocardial cell differentiation	IMP	J:165329
Biological Process	GO:0003197	endocardial cushion development	IMP	J:87765
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:87765
Biological Process	GO:0003157	endocardium development	IMP	J:119151
Biological Process	GO:0003160	endocardium morphogenesis	IMP	J:165329
Biological Process	GO:0007492	endoderm development	IMP	J:86975
Biological Process	GO:0008544	epidermis development	IGI	J:94517
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:87765
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:87765
Biological Process	GO:0030900	forebrain development	IGI	J:101735
Biological Process	GO:0030900	forebrain development	IMP	J:101735
Biological Process	GO:0007440	foregut morphogenesis	IMP	J:101154
Biological Process	GO:0010001	glial cell differentiation	IMP	J:99826
Biological Process	GO:0003241	growth involved in heart morphogenesis	IMP	J:170885
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:100563
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:94517
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0001947	heart looping	IGI	J:83358
Biological Process	GO:0061384	heart trabecula morphogenesis	IMP	J:165329
Biological Process	GO:0006959	humoral immune response	IGI	J:123631
Biological Process	GO:0001701	in utero embryonic development	IMP	J:25248
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IGI	J:123631
Biological Process	GO:0072602	interleukin-4 secretion	IGI	J:123631
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:90057
Biological Process	GO:0070986	left/right axis specification	IGI	J:83358
Biological Process	GO:0001889	liver development	IMP	J:91008
Biological Process	GO:0030324	lung development	IMP	J:96080
Biological Process	GO:0014031	mesenchymal cell development	IMP	J:133699
Biological Process	GO:0003192	mitral valve formation	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0045608	negative regulation of auditory receptor cell differentiation	IMP	J:218237
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:155019
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	IMP	J:147579
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:158135
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:218237
Biological Process	GO:0043086	negative regulation of catalytic activity	IDA	J:183220
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:25248
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:96080
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell proliferation	IMP	J:218237
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	ISO	J:164563
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:0060253	negative regulation of glial cell proliferation	IDA	J:82774
Biological Process	GO:0045662	negative regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:0010832	negative regulation of myotube differentiation	IDA	J:183961
Biological Process	GO:0050768	negative regulation of neurogenesis	IDA	J:183961
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:101735
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IDA	J:82774
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:187551
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:155019
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	IMP	J:105970
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation	IMP	J:183977
Biological Process	GO:2000737	negative regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	J:101495
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	J:183977
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	J:165329
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	J:87765
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated	IMP	J:155019
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated	IDA	J:101495
Biological Process	GO:0021915	neural tube development	IMP	J:25248
Biological Process	GO:0030182	neuron differentiation	IMP	J:39351
Biological Process	GO:0048663	neuron fate commitment	IGI	J:101735
Biological Process	GO:0061314	Notch signaling involved in heart development	IGI	J:165329
Biological Process	GO:0061314	Notch signaling involved in heart development	IMP	J:87765
Biological Process	GO:0061314	Notch signaling involved in heart development	IMP	J:170885
Biological Process	GO:0061314	Notch signaling involved in heart development	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:155856
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:144981
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:175008
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IC	J:58381
Biological Process	GO:0003270	Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation	IMP	J:158135
Biological Process	GO:0002051	osteoblast fate commitment	NAS	J:101495
Biological Process	GO:0003344	pericardium morphogenesis	IMP	J:165329
Biological Process	GO:0003344	pericardium morphogenesis	IMP	J:178290
Biological Process	GO:0003344	pericardium morphogenesis	IMP	J:87765
Biological Process	GO:1903849	positive regulation of aorta morphogenesis	IMP	J:144857
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:103603
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:90392
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:82774
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IDA	J:166398
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:170885
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:165329
Biological Process	GO:0008284	positive regulation of cell proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell proliferation	IGI	J:94813
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	ISO	J:155856
Biological Process	GO:1901189	positive regulation of ephrin receptor signaling pathway	IC	J:119151
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:147579
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:165329
Biological Process	GO:0045687	positive regulation of glial cell differentiation	ISO	J:155856
Biological Process	GO:0046427	positive regulation of JAK-STAT cascade	IDA	J:175195
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	IDA	J:114702
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	IGI	J:108327
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:155856
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:212472
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:133699
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:178290
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:89444
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:98581
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:123632
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:83945
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:102280
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:108327
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:101495
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	J:184125
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:87765
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IGI	J:108327
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:170885
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	J:119151
Biological Process	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA	J:183961
Biological Process	GO:0007221	positive regulation of transcription of Notch receptor target	ISO	J:155856
Biological Process	GO:0007221	positive regulation of transcription of Notch receptor target	IGI	J:83687
Biological Process	GO:0007221	positive regulation of transcription of Notch receptor target	IGI	J:197487
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated	IDA	J:40289
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated	IDA	J:166398
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated	IDA	J:82774
Biological Process	GO:0045070	positive regulation of viral genome replication	IMP	J:225486
Biological Process	GO:0050434	positive regulation of viral transcription	IMP	J:225486
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:104805
Biological Process	GO:0003184	pulmonary valve morphogenesis	ISO	J:164563
Biological Process	GO:0045607	regulation of auditory receptor cell differentiation	IMP	J:218237
Biological Process	GO:0003264	regulation of cardioblast proliferation	ISO	J:155856
Biological Process	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	IC	J:87765
Biological Process	GO:0030334	regulation of cell migration	IMP	J:165329
Biological Process	GO:0042127	regulation of cell proliferation	IGI	J:218237
Biological Process	GO:0042127	regulation of cell proliferation	ISO	J:155856
Biological Process	GO:0050793	regulation of developmental process	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:101154
Biological Process	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	IMP	J:104805
Biological Process	GO:1901201	regulation of extracellular matrix assembly	IMP	J:178290
Biological Process	GO:0010468	regulation of gene expression	IMP	J:65682
Biological Process	GO:0010468	regulation of gene expression	IMP	J:39351
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:39351
Biological Process	GO:0008593	regulation of Notch signaling pathway	IGI	J:212472
Biological Process	GO:0014807	regulation of somitogenesis	IMP	J:25248
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	IMP	J:218237
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	IGI	J:97176
Biological Process	GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	IMP	J:170885
Biological Process	GO:0006355	regulation of transcription, DNA-templated	IEA	J:72247
Biological Process	GO:0006355	regulation of transcription, DNA-templated	IEA	J:60000
Biological Process	GO:0032495	response to muramyl dipeptide	IDA	J:170396
Biological Process	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP	J:104805
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0048103	somatic stem cell division	IDA	J:83550
Biological Process	GO:0048103	somatic stem cell division	IGI	J:94813
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:100449
Biological Process	GO:0006351	transcription, DNA-templated	IEA	J:60000
Biological Process	GO:0035148	tube formation	ISO	J:164563
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	IMP	J:178290
Biological Process	GO:0048845	venous blood vessel morphogenesis	IMP	J:144857
Biological Process	GO:0060843	venous endothelial cell differentiation	IMP	J:165329
Biological Process	GO:0060412	ventricular septum morphogenesis	ISO	J:164563
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:119151

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---