GO Annotations Graph

• Symbol: Il2
• Name: interleukin 2
• ID: MGI:96548

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030246	carbohydrate binding	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	IDA	J:98326
Molecular Function	GO:0005125	cytokine activity	IMP	J:142709
Molecular Function	GO:0005125	cytokine activity	IDA	J:193599
Molecular Function	GO:0005125	cytokine activity	ISO	J:73065
Molecular Function	GO:0005125	cytokine activity	IDA	J:1013
Molecular Function	GO:0043208	glycosphingolipid binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0005134	interleukin-2 receptor binding	ISO	J:155856
Molecular Function	GO:0005134	interleukin-2 receptor binding	IDA	J:1013
Molecular Function	GO:0005134	interleukin-2 receptor binding	IDA	J:64279
Molecular Function	GO:0005134	interleukin-2 receptor binding	ISO	J:73065
Molecular Function	GO:0005134	interleukin-2 receptor binding	IDA	J:16175
Molecular Function	GO:0031851	kappa-type opioid receptor binding	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:193599
Cellular Component	GO:0005615	extracellular space	IDA	J:142709
Cellular Component	GO:0005615	extracellular space	IDA	J:116306
Cellular Component	GO:0005615	extracellular space	IDA	J:94032
Cellular Component	GO:0005615	extracellular space	IDA	J:129700
Cellular Component	GO:0005615	extracellular space	IDA	J:53400
Cellular Component	GO:0005615	extracellular space	IDA	J:39989
Cellular Component	GO:0005615	extracellular space	IDA	J:85084
Cellular Component	GO:0005615	extracellular space	IDA	J:14194
Cellular Component	GO:0005615	extracellular space	IDA	J:91286
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Biological Process	GO:0050798	activated T cell proliferation	IDA	J:64279
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:39989
Biological Process	GO:0050798	activated T cell proliferation	IDA	J:98326
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0071216	cellular response to biotic stimulus	IDA	J:199058
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:76678
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0010467	gene expression	IDA	J:241346
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0002366	leukocyte activation involved in immune response	ISO	J:164563
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	ISO	J:40789
Biological Process	GO:0045822	negative regulation of heart contraction	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:15223
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:39981
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IGI	J:220376
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IDA	J:98326
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:73065
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IDA	J:64279
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:39989
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:40789
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:39989
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:39989
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	ISO	J:155856
Biological Process	GO:0045582	positive regulation of T cell differentiation	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:191418
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:1013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:98326
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:145327
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:98326
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:112602
Biological Process	GO:0046013	regulation of T cell homeostatic proliferation	IMP	J:112602
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0042098	T cell proliferation	IDA	J:1013
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:98326
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA	J:98326