GO Annotations Graph

• Symbol: Hsf1
• Name: heat shock factor 1
• ID: MGI:96238

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:175085
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:74044
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0140296	general transcription initiation factor binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:140801
Molecular Function	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:142548
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0098847	sequence-specific single stranded DNA binding	ISO	J:155856
Molecular Function	GO:0097677	STAT family protein binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0061770	translation elongation factor binding	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:91051
Cellular Component	GO:0005737	cytoplasm	IDA	J:74044
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646345
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646359
Cellular Component	GO:0000791	euchromatin	ISO	J:155856
Cellular Component	GO:0000792	heterochromatin	ISO	J:155856
Cellular Component	GO:0000776	kinetochore	ISO	J:164563
Cellular Component	GO:0097431	mitotic spindle pole	ISO	J:164563
Cellular Component	GO:0097165	nuclear stress granule	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:140801
Cellular Component	GO:0005634	nucleus	IDA	J:74044
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0045120	pronucleus	IDA	J:91051
Cellular Component	GO:0101031	protein folding chaperone complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IGI	J:93301
Biological Process	GO:0008283	cell population proliferation	IGI	J:93301
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:155856
Biological Process	GO:1904385	cellular response to angiotensin	ISO	J:155856
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0071280	cellular response to copper ion	ISO	J:164563
Biological Process	GO:0072738	cellular response to diamide	ISO	J:164563
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:155856
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0034605	cellular response to heat	ISO	J:155856
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0071478	cellular response to radiation	ISO	J:155856
Biological Process	GO:1903936	cellular response to sodium arsenite	ISO	J:164563
Biological Process	GO:0034620	cellular response to unfolded protein	ISO	J:164563
Biological Process	GO:0006952	defense response	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0001892	embryonic placenta development	IMP	J:58383
Biological Process	GO:0001892	embryonic placenta development	IMP	J:58383
Biological Process	GO:0060136	embryonic process involved in female pregnancy	IMP	J:58383
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:93301
Biological Process	GO:0007143	female meiotic nuclear division	IMP	J:175085
Biological Process	GO:0001701	in utero embryonic development	IMP	J:58383
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0009299	mRNA transcription	ISO	J:164563
Biological Process	GO:0051028	mRNA transport	IEA	J:60000
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IGI	J:93301
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0090084	negative regulation of inclusion body assembly	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:58383
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249878
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:281244
Biological Process	GO:0090261	positive regulation of inclusion body assembly	ISO	J:155856
Biological Process	GO:0045651	positive regulation of macrophage differentiation	ISO	J:164563
Biological Process	GO:1904528	positive regulation of microtubule binding	ISO	J:155856
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:1900365	positive regulation of mRNA polyadenylation	ISO	J:164563
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:58383
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:142548
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:1900034	regulation of cellular response to heat	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0090231	regulation of spindle checkpoint	IMP	J:175085
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032355	response to estradiol	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0009408	response to heat	IMP	J:58383
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:58383
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IGI	J:88035
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:58383