GO Annotations Graph

• Symbol: Cd4
• Name: CD4 antigen
• ID: MGI:88335

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015026	coreceptor activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019865	immunoglobulin binding	ISO	J:155856
Molecular Function	GO:0042011	interleukin-16 binding	ISO	J:164563
Molecular Function	GO:0042012	interleukin-16 receptor activity	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0042289	MHC class II protein binding	ISO	J:164563
Molecular Function	GO:0042289	MHC class II protein binding	IBA	J:265628
Molecular Function	GO:0023026	MHC class II protein complex binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:115170
Molecular Function	GO:0005515	protein binding	IPI	J:204615
Molecular Function	GO:0005515	protein binding	IPI	J:166038
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:129700
Cellular Component	GO:0005788	endoplasmic reticulum lumen	IDA	J:104449
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:104449
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:39748
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174697
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:63425
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:30163
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:98417
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:172134
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31364
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141145
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:165738
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:103896
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:27768
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:80063
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155686
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:96628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92721
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:140498
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141431
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:53400
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:149909
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:39981
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:86758
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92334
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:60915
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29796
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:120804
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:152384
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:97996
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:14194
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:177992
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:145327
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29797
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92721
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:41170
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:29797
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:34311
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:27768
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:35057
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:157744
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:137854
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31364
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163829
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:160369
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0045121	membrane raft	IDA	J:89862
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:225417
Cellular Component	GO:0005886	plasma membrane	ISO	J:73065
Cellular Component	GO:0005886	plasma membrane	IDA	J:87276
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:41170
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:225416
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:41170
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0001816	cytokine production	IGI	J:20865
Biological Process	GO:0001816	cytokine production	IMP	J:20865
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:87077
Biological Process	GO:0035397	helper T cell enhancement of adaptive immune response	IMP	J:68957
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0030225	macrophage differentiation	ISO	J:164563
Biological Process	GO:0032507	maintenance of protein location in cell	ISO	J:89862
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:41170
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IDA	J:41170
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0045657	positive regulation of monocyte differentiation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:41170
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	IDA	J:80063
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0046598	positive regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0050863	regulation of T cell activation	ISO	J:164563
Biological Process	GO:0042110	T cell activation	ISO	J:155856
Biological Process	GO:0042110	T cell activation	IBA	J:265628
Biological Process	GO:0042110	T cell activation	IDA	J:80063
Biological Process	GO:0030217	T cell differentiation	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	ISS	J:113701
Biological Process	GO:0045058	T cell selection	ISO	J:164563
Biological Process	GO:0045058	T cell selection	ISS	J:45168