GO Annotations Graph

• Symbol: Srebf1
• Name: sterol regulatory element binding transcription factor 1
• ID: MGI:107606

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:117710
Molecular Function	GO:0003682	chromatin binding	IDA	J:117710
Molecular Function	GO:0003682	chromatin binding	IDA	J:117710
Molecular Function	GO:0003682	chromatin binding	IDA	J:96459
Molecular Function	GO:0003682	chromatin binding	IDA	J:152612
Molecular Function	GO:0003677	DNA binding	IDA	J:177249
Molecular Function	GO:0003677	DNA binding	IDA	J:75012
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISS	J:118822
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:108164
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:35770
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IMP	J:175815
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:184939
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:182476
Molecular Function	GO:0005515	protein binding	IPI	J:120098
Molecular Function	GO:0005515	protein binding	IPI	J:184939
Molecular Function	GO:0005515	protein binding	IPI	J:117710
Molecular Function	GO:0005515	protein binding	IPI	J:87173
Molecular Function	GO:0005515	protein binding	IPI	J:125929
Molecular Function	GO:0005515	protein binding	IPI	J:117710
Molecular Function	GO:0005515	protein binding	IPI	J:117710
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	IPI	J:177249
Molecular Function	GO:0019901	protein kinase binding	IPI	J:172248
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:184939
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:184939
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:87173
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:87173
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0032810	sterol response element binding	ISO	J:164563
Molecular Function	GO:0032810	sterol response element binding	ISS	J:118822
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:172248
Cellular Component	GO:0005737	cytoplasm	IDA	J:101203
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	TAS	Reactome:R-MMU-1368139
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:65994
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2426184
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2426196
Cellular Component	GO:0005634	nucleus	IDA	J:65994
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:172248
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:184939
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0009267	cellular response to starvation	ISO	J:155856
Biological Process	GO:0009267	cellular response to starvation	IDA	J:118822
Biological Process	GO:0006695	cholesterol biosynthetic process	IMP	J:43570
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:155856
Biological Process	GO:0007623	circadian rhythm	IEP	J:211246
Biological Process	GO:0045444	fat cell differentiation	IMP	J:184939
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:117710
Biological Process	GO:0030073	insulin secretion	IMP	J:129731
Biological Process	GO:0008610	lipid biosynthetic process	IDA	J:172248
Biological Process	GO:0008610	lipid biosynthetic process	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:184939
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:129731
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117710
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:125929
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	IDA	J:35770
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	IDA	J:108164
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	IMP	J:101307
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	IMP	J:43570
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:65994
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	TAS	J:65994
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:175815
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	IMP	J:175815
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	IDA	J:199237
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:87173
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:43570
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:130829
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117710
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:87173
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:129731
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	IDA	J:177249
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	IMP	J:101307
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:172248
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:79403
Biological Process	GO:0019217	regulation of fatty acid metabolic process	IMP	J:152612
Biological Process	GO:0003062	regulation of heart rate by chemical signal	IMP	J:130829
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:133587
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:108164
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:175815
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:35770
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009749	response to glucose	IMP	J:133587
Biological Process	GO:0032933	SREBP signaling pathway	ISO	J:164563
Biological Process	GO:0032933	SREBP signaling pathway	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:129731