GO Annotations Graph

• Symbol: Ddx5
• Name: DEAD box helicase 5
• ID: MGI:105037

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0035500	MH2 domain binding	ISO	J:164563
Molecular Function	GO:0003730	mRNA 3'-UTR binding	ISO	J:164563
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IBA	J:265628
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0036002	pre-mRNA binding	ISO	J:164563
Molecular Function	GO:0070878	primary miRNA binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:240379
Molecular Function	GO:0005515	protein binding	IPI	J:236962
Molecular Function	GO:0005515	protein binding	IPI	J:240379
Molecular Function	GO:0005515	protein binding	IPI	J:190257
Molecular Function	GO:0005515	protein binding	IPI	J:185950
Molecular Function	GO:0005515	protein binding	IPI	J:185950
Molecular Function	GO:0005515	protein binding	IPI	J:93135
Molecular Function	GO:0005515	protein binding	IPI	J:153063
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ISO	J:164563
Molecular Function	GO:0043021	ribonucleoprotein complex binding	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	IDA	J:186636
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:155856
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:164563
Molecular Function	GO:0003724	RNA helicase activity	IBA	J:265628
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	IDA	J:93135
Cellular Component	GO:0071013	catalytic step 2 spliceosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IC	J:93135
Cellular Component	GO:1990904	ribonucleoprotein complex	IBA	J:265628
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:142821
Cellular Component	GO:0005681	spliceosomal complex	IEA	J:60000
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	IMP	J:240379
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	IBA	J:265628
Biological Process	GO:0030521	androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0007623	circadian rhythm	IMP	J:185950
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0061614	miRNA transcription	IMP	J:240379
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0009299	mRNA transcription	ISO	J:164563
Biological Process	GO:0045445	myoblast differentiation	IMP	J:240379
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	ISO	J:164563
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:93135
Biological Process	GO:0031053	primary miRNA processing	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	IGI	J:186636
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	J:238450
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0060765	regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045667	regulation of osteoblast differentiation	IMP	J:182495
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	IMP	J:182387
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045069	regulation of viral genome replication	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0008380	RNA splicing	IEA	J:60000